慢性心力衰竭患者血清氨基末端B型脑钠肽前体和超敏C反应蛋白及糖类抗原-125水平分析

Analysis of NT-pro BNP, hs-CRP and CA-125 Levels in Patients with Chronic Heart Failure

目的分析慢性心力衰竭患者血清氨基末端B型脑钠肽前体(NT-proBNP)、超敏C反应蛋白(hypersensitive C-reactive protein, hs-CRP)和糖类抗原-125(carbohydrate antigen-125, CA-125)水平特征。方法选取2019年1月-2020年12月沈阳医学院附属第二医院心血管内科收治的82例慢性心力衰竭患者纳入观察组,选取同期进行健康体检的82例健康者纳入对照组。对比分析两组患者血清NT-pro BNP、hs-CRP和CA-125水平,以及观察组治疗前后和不同心功能分级患者血清NT-pro BNP、hs-CRP和CA125水平的差异,分析心功能分级与血清NT-pro BNP、hs-CRP和CA-125水平的关系。结果观察组治疗前血清NT-pro BNP、hs-CRP和CA-125水平高于对照组,差异均具有统计学意义(P<0.05)。观察组治疗后血清NT-pro BNP、hs-CRP和CA-125水平较治疗前降低,差异均具有统计学意义(P<0.05)。观察组心功能Ⅲ级和Ⅳ级患者的血清NT-pro BNP、hs-CRP和CA-125水平高于心功能Ⅰ级和Ⅱ级患者,差异均具有统计学意义(P<0.05)。Spearman相关性分析显示,NT-pro BNP、hs-CRP和CA-125水平与患者的心功能分级呈正相关。结论慢性心力衰竭患者血清NT-pro BNP、hs-CRP和CA-125表达水平高于健康人群,且这3项指标与患者心功能分级呈正相关,可作为慢性心力衰竭患者病情评估的潜在指标。

Objective To investigate the levels of serum NT-pro BNP, high sensitivity C-reactive protein hs-CRP and CA125 in patients with chronic heart failure, and to compare the levels before and after treatment. Methods From January 2019 to December 2020, a total of 82 patients with chronic heart failure admitted to the cardiovascular department of the Second Affiliated Hospital of Shenyang Medical College were included in the observation group,and 82 healthy people in the same period were included in the control group. The general clinical data, routine blood biochemical indexes were detected, and the serum NT-pro BNP, hs-CRP and CA125 of the two groups were compared and analyzed. Results Before treatment, the serum levels of NT-pro BNP, hs-CRP and CA125 in the observation group were significantly higher than those in the control group(P < 0.05). In observation group, the levels of NTpro BNP, hs-CRP and CA125 after treatment were significantly lower than those before treatment(P < 0.05). In observation group, serum NT-pro BNP, hs-CRP and CA125 levels in patients with grade Ⅲ and Ⅳ heart function were significantly higher than patients with grade Ⅰ and Ⅱ heart function(P < 0.05). Spearman correlation analysis indicated that the serum levels of NT-pro BNP, hs-CRP and CA125 were positively correlated with cardiac function. Conclusion The levels of NT-pro BNP, hs-CRP and CA125 in patients with chronic heart failure were significantly higher than those in healthy controls, and were positively correlated with the cardiac function grade of the patients. They are potential indicators for disease assessment in patients with chronic heart failure.