雷贝拉唑联合奥曲肽治疗上消化道出血的疗效及对血小板、纤维蛋白原水平的影响

Effects of Rabeprazole Combined with Octreotide in the Treatment of Upper Gastrointestinal Bleeding and the Effects on Platelet and Fibrinogen Levels

目的探讨雷贝拉唑联合奥曲肽治疗上消化道出血的疗效及对血小板、纤维蛋白原水平的影响。方法选取2017年5月至2019年12月辽阳市太子河区医院收治的88例上消化道出血患者作为研究对象,随机分为对照组与观察组,各44例。对照组患者给予奥曲肽治疗,观察组患者给予雷贝拉唑联合奥曲肽治疗,比较两组治疗有效率、输血量、止血时间、再出血率、血小板及纤维蛋白原。结果观察组患者治疗有效率95.45%高于对照组81.82%,差异有统计学意义(P<0.05)。观察组患者输血量、止血时间及再出血率低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者血小板和纤维蛋白原水平比较差异无统计学意义(P>0.05),治疗后两组血小板和纤维蛋白原水平上升,且观察组患者血小板和纤维蛋白原水平高于对照组,差异有统计学意义(P<0.05)。结论雷贝拉唑联合奥曲肽能够将上消化道出血患者的血小板和纤维蛋白原水平有效提高,止血的效果较好,是一种较为理想的治疗方式。

Objective To investigate the effect of rabeprazole combined with octreotide in the treatment of upper gastrointestinal bleeding and the effects on platelet and fibrinogen levels. Methods A total of 88 patients with upper gastrointestinal bleeding admitted to Taizihe District Hospital of Liaoyang City from May 2017 to December 2019 for treatment were randomly divided into a control group(44 cases) and an observation group(44 cases). The control group was treated with octreotide and the observation group were treated with rabeprazole combined with octreotide. The treatment efficiency, blood transfusion volume, hemostasis time,rebleeding rate, platelets and fibrinogen were compared and analyzed between the 2 groups. Results The total effective rate of treatment in the observation group was 95.45% higher than that of the control group 81.82%, the difference was statistically significant(P<0.05). The blood transfusion, hemostasis time and rebleeding rate of the observation group were lower than those of the control group, the difference was statistically significant(P<0.05). Before treatment, there was no significant difference in the levels of platelets and fibrinogen between the 2 groups of patients(P>0.05). After treatment, the levels of platelets and fibrinogen in the 2 groups increased, and the level of platelets and fibrinogen of the observation group were higher than those of the control group and there were statistical differences(P<0.05). Conclusion Rabeprazole combined with octreotide can effectively increase the levels of platelets and fibrinogen in patients with upper gastrointestinal bleeding, and the effect of hemostasis is relatively good.It is an ideal treatment.