注射用白眉蛇毒血凝酶联合奥美拉唑治疗上消化道出血患者的临床效果

Analysis of the Clinical Effect of Bangting Combined with Omeprazole in the Treatment of Patients with Upper Gastrointestinal Bleeding

目的探讨注射用白眉蛇毒血凝酶联合奥美拉唑治疗上消化道出血患者的临床效果。方法选取2018年10月至2020年10月盘锦市人民医院收治的28例上消化道出血患者作为研究对象,随机分为对照组(奥美拉唑治疗)与观察组(注射用白眉蛇毒血凝酶联合奥美拉唑治疗),各14例。比较两组患者治疗有效率、血红蛋白水平、Rockall评分及不良反应情况。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05);治疗后,观察组血红蛋白水平高于对照组,差异有统计学意义(P<0.05);治疗后,观察组低危患者比例显著高于对照组,而中危及高危患者比例显著低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论注射用白眉蛇毒血凝酶联合奥美拉唑可有效改善消化道出血患者临床症状及体征,提高血红蛋白水平,且不良反应发生率较低,安全可靠,效果确切。

Objective To explore the effects of Bangting(Hemocoagulase from the venom of the snake venom) combined with rabeprazole sodium enteric-coated tablets on patients with upper gastrointestinal bleeding. Methods A total of 28 patients with upper gastrointestinal bleeding admitted to People’s Hospital of Panjin City from October 2018 to October 2020 were selected as the research objects and were randomly divided into a control group(Omeprazole treatment) and an observation group(Bangting combined with rabeprazole sodium enteric-coated tablets), with 14 cases in each group. Treatment efficiency, hemoglobin level, Rockall score, and adverse reactions of the 2 groups were compared. Results The observation group had a higher effective rate of treatment, and the difference was statistically significant(P<0.05);After treatment, the hemoglobin level of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05);after treatment, the proportion of low-risk patients in the observation group was significantly higher than that of the control group, while the proportion of middle-risk and high-risk patients was significantly lower than that of the control group. The difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group was lower than that of the control group, and the difference was statistically significant(P<0.05).After treatment, the proportion of low-risk patients in the observation group was significantly higher than that of the control group, while the proportion of middle-risk and high-risk patients was significantly lower than that of the control group, the difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group was lower than the control group, the difference was statistical significance(P<0.05). Conclusion In the treatment of upper gastrointestinal bleeding, Bangting combined with rabeprazole sodium enteric-coated tablets can effectively improve the clinical symptoms and signs of patients, increase the level of hemoglobin, and the incidence of adverse reactions in the treatment of Bangting is relatively high. It is low, safe, reliable, and effective.