依达拉奉联合阿托伐他汀钙治疗急性脑梗死患者的临床疗效

Curative Effects of Edaravone Combined with Atorvastatin Calcium in the Treatment of Patients with Acute Cerebral Infarction

目的探讨依达拉奉联合阿托伐他汀钙治疗急性脑梗死患者的疗效。方法选取2019年1月至2020年1月于大连市中心医院神经内科住院治疗的急性脑梗死患者68例作为研究对象,据其住院病例号码随机分为他汀组与联合组,各34例。两组患者接受抗血小板聚集、改善循环、降低颅内压、改善脑水肿等基础治疗,并监测各项生命指征指标,如血压、心率、血氧饱和度、体温等。同时,他汀组患者联合阿托伐他汀钙片治疗,联合组患者在他汀组基础上联合依达拉奉注射液治疗。比较两组治疗前后血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平,神经功能缺损程度评分及治疗有效率。结果治疗后,他汀组及联合组Hcy、hs-CRP、MDA水平及NIHSS评分较治疗前降低,SOD水平较治疗前升高,联合组改变程度更显著,差异有统计学意义(P<0.05);他汀组治疗有效率为70.59%,联合组治疗有效率为94.12%,联合组明显高于他汀组(P<0.05)。结论依达拉奉联合阿托伐他汀钙具有清除氧自由基、缓解平滑肌痉挛、加速脑组织血液循环、遏制炎症反应发生、促神经修复等作用,可改善急性脑梗死患者肢体活动障碍、神经损伤等症状。

Objective To explore the efficacy of edaravone combined with atorvastatin calcium in the treatment of patients with acute cerebral infarction. Methods A total of 68 patients with acute cerebral infarction admitted to the Department of Neurology,Dalian Central Hospital from January 2019 to January 2020 were selected as the research objects. According to their hospitalized case numbers, they were randomly divided into a statin group and a combined group, with 34 cases in each group. Both groups of patients received basic treatments such as anti-platelet aggregation, improving circulation, lowering intracranial pressure, and improving cerebral edema, and monitored various vital signs, such as blood pressure, heart rate, blood oxygen saturation, and body temperature. Meanwhile, patients in the statin group were treated with atorvastatin calcium tablets, and patients in the combination group were treated with edaravone injection plus atorvastatin calcium tablets. Serum homocysteine(Hcy), high sensitivity C-reactive protein(hs-CRP), superoxide dismutase(SOD), malondialdehyde(MDA) levels, neurological deficit score and treatment before and after treatment between the two groups were compared. Results After treatment, the Hcy level, hs-CRP level, MDA content and NIHSS score of the statin group and the combination group were lower than before the treatment, and the SOD level was higher than that before the treatment, and the degree of change in the combination group was more significant, the difference was statistically significant(P<0.05);the effective rate of the statin group was 70.59%, and the effective rate of the combination group was 94.12%, which was significantly higher than that of the statin group(P<0.05). Conclusion Edaravone combined with atorvastatin calcium has the effects of scavenging oxygen free radicals, alleviating smooth muscle spasm, accelerating blood circulation in brain tissue, inhibiting inflammation, promoting nerve repair, etc., and improving limb dysfunction and nerve damage in patients with acute cerebral infarction and other symptoms.