吸入用布地奈德混悬液雾化联合盐酸丙卡特罗治疗喘息性支气管炎患儿的疗效

Clinical Effects of Inhalation Budesonide Suspension Nebulization combined with Procaterol Hydrochloride in the Treatment of Child Patients with Asthmatic Bronchitis

目的探讨吸入用布地奈德混悬液雾化联合盐酸丙卡特罗治疗喘息性支气管炎患儿的临床效果。方法选取2018年7月至2020年12月辽宁省健康产业集团阜新矿总医院收治的喘息性支气管炎患儿96例作为研究对象,依据治疗方案不同分为观察组与对照组,各48例。对照组接受吸入用布地奈德混悬液雾化治疗,观察组在对照组基础上加用盐酸丙卡特罗治疗,比较两组疗效、症状(三凹征、肺部哮鸣音、喘息、咳嗽)消退时间及治疗前、治疗7d、14d肺功能[潮气呼气中期流速(ME)/潮气吸气中期流速(MI)、潮气呼气峰流速(PTEF)]、血清炎症介质[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、氧化应激指标[总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)、丙二醛(MDA)]水平。结果观察组治疗有效率为95.83%高于对照组81.25%(P<0.05);观察组三凹征消退时间、肺部哮鸣音消退时间、喘息消退时间、咳嗽消退时间短于对照组(P<0.05);治疗7 d、14 d观察组ME/MI、PTEF低于对照组(P<0.05);治疗7 d、14 d观察组血清TNF-α、IL-6水平低于对照组(P<0.05);治疗7 d、14 d观察组血清T-AOC、MDA水平低于对照组,血清SOD水平高于对照组,差异有统计学意义(P<0.05)。结论吸入用布地奈德混悬液雾化联合盐酸丙卡特罗治疗喘息性支气管炎患儿效果确切,可有效改善临床症状,调节肺功能,降低血清炎症介质水平,改善氧化应激。

Objective To explore the effect of inhalation budesonide suspension nebulization combined with Procaterol hydrochloride in the treatment of child patients with asthmatic bronchitis.Methods A total of 96 child patients with asthmatic bronchitis admitted to Fuxin Mining General Hospital from July 2018 to December 2020 were selected as the research objects.According to the different treatment plans,they were divided into an observation group and a control group.The control group(48 cases)received budesine for inhalation for the treatment and the observation group(48 cases).And the observation group was treated with procaterol hydrochloride on the basis of the control group.The efficacy,symptoms(three-concave sign,lung wheezing,wheezing,cough)subsidence time and lung function before treatment,7 days and 14 days after treatment[Mid tidal expiratory flow rate(ME)/Mid tidal inspiratory flow rate(MI),tidal peak expiratory flow rate(PTEF)],serum inflammatory mediators[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)],oxidative stress index[total antioxidant capacity(T-AOC),superoxide dismutase(SOD),malondialdehyde(MDA)]levels were compared.Results The total effective rate of the study group was 95.83%(46/48)higher than that of the control group 81.25%(39/48,P<0.05);the observation group’s tri-concave sign subsided time,lung wheeze subsided time,wheeze subsided time,cough regression time was shorter than that of the control group(P<0.05);ME/MI and PTEF of the observation group were lower than those of the control group(P<0.05)on the 7 th and 14 th day of treatment;the serum TNF-αand IL-of the observation group on the 7 th and 14 th day of treatment was lower than that of the control group(P<0.05);the serum T-AOC and MDA levels of the observation group were lower than those of the control group on the 7 th and 14 th day of treatment,and the serum SOD level was higher than that of the control group(P<0.05).Conclusion Inhalation of budesonide suspension combined with procaterol hydrochloride is effective in the treatment of children with asthmatic bronchitis.It can effectively improve clinical symptoms,regulate lung function,reduce serum levels of inflammatory mediators,and improve oxidative stress.