外周血Periostin表达水平与股骨头坏死塌陷进程的相关性研究

Study on the Correlation between the Expression Level of Periostin in Peripheral Blood and the Collapse Process of Femoral Head Necrosis

目的研究外周血Periostin表达与股骨头坏死塌陷进程的关系。方法选取2016年8月~2019年5月石家庄市人民医院收治的110例股骨头坏死患者作为研究组。另纳入同期进行体检的110例非股骨头坏死受试者作为对照组。测定受试者外周血中Periostin水平。比较研究组和对照组Periostin水平的差异;比较研究组患者不同病因及不同分期的Periostin水平差异;比较研究组股骨头坏死塌陷前后的Periostin水平差异;分析研究组患者外周血中Periostin水平与病因及分期的相关性;采用ROC曲线分析外周血中Periostin在股骨头坏死塌陷的诊断效能。结果研究组受试者外周血中Periostin水平(0.65±0.10)显著高于对照组(0.65±0.10),差异有统计学意义(t=11.167,P<0.05)。研究组患者中国际骨循环研究会(ARCO)不同分期组间比较差异具有统计学意义(F=15.567,P<0.05),且Ⅲ期和Ⅳ期患者外周血中Periostin水平(0.82±0.14,0.87±0.15)显著高于Ⅱ期患者(0.69±0.12),组间比较差异均具有统计学意义(均P<0.05)。病因为酒精性、激素性、特发性及创伤性患者外周血中Periostin水平比较差异无统计学意义(F=0.563,P>0.05)。研究组患者股骨头坏死塌陷后(0.92±0.23)与塌陷前(0.67±0.11)相比外周血中Periostin水平显著升高,差异有统计学意义(t=6.465,P<0.05)。研究组Periostin水平与ARCO分期呈正相关(r=0.563,P<0.05)。股骨头坏死塌陷患者外周血中Periostin的AUC及95%CI分别为0.841(95%CI,0.786~0.895,P<0.001),提示外周血中Periostin对股骨头坏死塌陷诊断效能较高。结论外周血中Periostin表达与股骨头坏死塌陷有密切关系,股骨头坏死塌陷后外周血中Periostin水平显著升高,对股骨头坏死塌陷具有一定的诊断价值。

Objective To study the relationship between the expression of Periostin in peripheral blood and the collapse process of femoral head necrosis.Methods Selected 110 patients with femoral head necrosis admitted to Shijiazhuang People’s Hospital from August 2016 to May 2019 as the research group.In addition,110 subjects with non-femoral head necrosis admitted to the hospital for physical examination at the same time were included as the control group.The Periostin protein level in the peripheral blood of the subjects was determined.Compared the difference of Periostin levels between the study group and the control group.Compared the differences in the levels of Periostin in the study group with different causes and different stages,and compared the difference of Periodin levels before and after the collapse of femoral head necrosis in the study group.Analyzed the correlation between the level of Periostin in the peripheral blood of the study group and the etiology and stage,and analyzed the diagnostic efficacy of Periostin in peripheral blood for femoral head necrosis collapse.Results The level of Periostin in the peripheral blood of the subjects in the study group(0.65±0.10)was significantly higher than that in the control group(0.65±0.10),the difference was statistically significant(t=11.167,P<0.05).The difference between the ARCO stages of the study group was statistically significant(P<0.05),and the level of Periostin in the peripheral blood of patients with stage Ⅲ and Ⅳ(0.82±0.14,0.87±0.15)was significantly higher than that of patients with stage Ⅱ(0.69±0.12),and the differences between the groups were statistically significant(P<0.05).The cause of the cause was that there was no statistically significant difference in the levels of Periostin in the peripheral blood of alcoholic,hormonal,idiopathic and trauma patients(P>0.05).After the femoral head necrosis of the study group collapsed,the level of Periostin in the peripheral blood(0.92±0.23)was significantly higher than that before the collapse(0.67±0.11),the difference was statistically significant(t=6.465,P<0.05).The level of Periodin in the study group was positively correlated with ARCO staging(r=0.563,P<0.05).The AUC and 95%CI of Periostin in peripheral blood of patients with femoral head necrosis collapse were 0.841(95%CI,0.786~0.895,P<0.001),and it suggesting that Periostin in peripheral blood had a higher diagnostic efficiency for femoral head necrosis collapse.Conclusion The expression of Periostin in peripheral blood was closely related to the collapse of femoral head necrosis.After the collapse of femoral head necrosis,the level of Periostin in peripheral blood increases significantly,which has certain diagnostic value for femoral head necrosis collapse.