高毒力肺炎克雷伯菌对碳青霉烯类耐药机制研究进展

Research Progress on the Mechanism of Hypervirulent Klebsiella Pneumoniae Resistance to Carbapenems

高毒力肺炎克雷伯菌(hypervirulent Klebsiella pneumoniae,hvKP)在临床分离株中检出率日益增加,携带多种毒力基因,致病力强,常导致严重的社区获得性感染。通常hvKP耐药率低,临床治愈率高,但碳青霉烯类耐药株(carbpenem-resistant hypervirulent Klebsiella pneumoniae,CR-hvKP)的出现打破了这一平衡。CR-hvKP集合高毒力、高耐药等特性,亦有“超级细菌”之称,极易造成致命性传播,迅速引发全球高度关注。该文将hvKP对碳青霉烯类耐药机制作如下综述,旨在明确CR-hvKP的形成途径,为遏制CR-hvKP的出现及传播提供参考。

The detection rate of hypervirulent Klebsiella pneumoniae(hvKP)in clinical isolates is increasing.It carries multiple virulence genes and is highly pathogenic,often leading to serious community-acquired infections.Generally,hvKP has a low drug resistance rate and a high clinical cure rate.However,the emergence of carbpenem-resistant hypervirulent Klebsiella pneumoniae(CR-hvKP)has broken this balance.CR-hvKP combines high virulence,high drug resistance and other characteristics,and is also known as“superbug”.It is easy to cause fatal transmission and quickly arouses global attention.This article summarizes the mechanism of hvKP resistance to carbapenems,aiming to clarify the formation theory of CR-hvKP,and provide a reference for curbing the emergence and spread of CR-hvKP.