弥漫性低级别胶质瘤相关癫痫的术后疗效及影响因素

Postoperative outcomes and influencing factors of diffuse low-grade glioma-related epilepsy

分析福建医科大学附属第一医院神经外科于2015年1月至2018年12月收治的49例弥漫性低级别胶质瘤相关癫痫患者的临床、病理特征及术后疗效,术后随访1年时,预后良好组33例(67.3%),预后不良组16例(32.7%),多因素logistic回归分析肿瘤次全切除(OR=5.56,95%CI:1.21~25.44,P=0.027)、术后未行放射治疗(OR=9.24,95%CI:2.05~41.75,P=0.004)是术后癫痫预后不良的相关因素。故而弥漫性低级别胶质瘤相关癫痫患者,全切除肿瘤及术后行放射治疗有利于癫痫的控制。

The clinical and pathological features and postoperative outcomes of 49 patients with diffuse low-grade glioma-related epilepsy who were admitted to the Department of Neurosurgery of the First Affiliated Hospital of Fujian Medical University from January 2015 to December 2018 were analyzed.After 1-year follow-up,33 patients(67.3%)in the good prognosis group and 16 patients(32.7%)in the poor prognosis group were enrolled.Multivariate logistic regression analysis indicatedthat subtotal tumor resection(OR=5.56,95%CI:1.21-25.44,P=0.027)and no postoperative radiotherapy(OR=9.24,95%CI:2.05-41.75,P=0.004)were the risk factors for poor prognosis of postoperative epilepsy.Therefore,for patients with diffuse low-grade glioma-related epilepsy,total tumor resection and postoperative radiotherapy are beneficial to the control of epilepsy.