缺血性脑白质疏松症病变体积比率与认知功能的相关性研究

Correlation between lesion volume ratio and cognitive function in ischemic leukoaraiosis

目的探讨缺血性脑白质疏松症(LA)病变体积比率与认知水平和动脉灌流等相关因素之间的关系。方法选取2012年3-12月就诊于大连市中心医院临床确诊的LA患者54例,采集患者脑白质病变体积比率、蒙特利尔评估量表(MoCA量表)得分和颈动脉平均流速等信息,分析LA患者病变体积比率与MoCA评分、认知障碍的特点和颈动脉平均流速的相关性。结果LA病变体积比率与MoCA评分呈负相关(r=-0.59,P<0.01);LA病变体积比率与颈内动脉平均流速呈负相关(r=-0.37,P<0.01);MoCA量表认知亚组受试者工作特征曲线下面积,延迟记忆力(1.000)>视觉空间/执行功能(0.970)=抽象力(0.970)>语言能力(0.960)>注意力(0.888)。结论LA患者脑白质病变体积比率愈大,认知障碍程度愈重;认知障碍以延迟记忆力功能、视觉空间/执行功能、抽象能力和语言能力受损为著。

Objective To investigate the relationship between the volume ratio of ischemic leukoaraiosis(LA)and cognitive level and arterial perfusion.Methods Fifty-four patients,who was hospitalized in Dalian Central Hospital and diagnosed as LA clinically during the time of March to December in 2012,were selected to collect the information of the volume ratio of white matter disease,MoCa score and the average flow rate of carotid artery.The correlation between the volume ratio of white matter disease and MoCa score,cognitive impairment and the average flow rate of carotid artery were analyzed.Results The volume ratio of LA lesions was negatively correlated with MOCA score(r=-0.59,P<0.01);the volume ratio of LA lesions was negatively correlated with the mean flow rate of internal carotid artery(r=-0.37,P<0.01).Quantity order of the area under receiver operating characteristic(ROC)curve of MoCA cognitive subgroup was as following:delayed memory(1.000)>visual space/executive function(0.970)=abstract force(0.970)>language ability(0.960)>attention(0.888).Conclusions The larger the volume ratio of leukopathy in LA patients,the more serious the cognitive impairment,especially the cognitive impairment of impairment of memory delay,visual space/executive function,abstract ability and language ability.