摘要
血管老化是血管的结构和功能随年龄增长呈现年龄依赖性的退行性改变,可导致心血管疾病的患病风险显著增加。动脉粥样硬化是多种心血管疾病的病理生理基础,血管老化在动脉粥样硬化的发生发展中发挥重要作用。有效评估血管老化对动脉粥样硬化性心血管疾病的临床诊疗意义重大。本文总结了血管老化的结构和功能性变化,阐述血管老化过程中血管细胞端粒磨损、线粒体功能障碍和炎性反应在动脉粥样硬化中的重要作用,以期为动脉粥样硬化疾病的预防和诊治提供新思路。
Vascular aging is an age-dependent degeneration of vascular structure and function,which can lead to an increased risk of cardiovascular diseases.Atherosclerosis is an essential pathogenesis of cardiovascular diseases.Vascular aging plays an important role in the progression of atherosclerosis.Effective evaluation of vascular aging is necessary for the clinical treatment of atherosclerotic diseases.This review summarized the structural and functional changes of vascular aging,and highlighted the important roles of telomere attrition,mitochondrial dysfunction and inflammation of vascular cells in the process of atherosclerosis,aiming to provide new impetus for the clinical treatment of atherosclerotic diseases.
作者
张琦悦
张伟丽
ZHANG Qi-yue;ZHANG Wei-li(State Key Laboratory of Cardiovascular Diseases, National Center for Cardiovascular Diseases and Fuwai Hospital, CAMS & PUMC, Beijing 100037, China)
出处
《基础医学与临床》
2022年第3期372-377,共6页
Basic and Clinical Medicine
基金
国家自然科学基金面上项目(82070373)。
