1169例冻融胚胎移植周期的临床妊娠结局分析

Clinical pregnancy outcome analysis of 1169 frozen-thawed embryo transfer cycles

目的探讨影响冻融胚胎移植(FET)妊娠结局的相关因素。方法回顾分析2017年1月至2019年12月在深圳市妇幼保健院行FET的1169对夫妇的临床数据,采用单因素分析和Logistic多因素回归分析探讨FET妊娠结局的相关因素。结果1169个FET周期的临床妊娠率为50.13%;单因素分析表明,年龄>35岁、不孕年限>6年显著降低胚胎种植率和临床妊娠率(P<0.01),但囊胚或多个优胚数目移植可提高胚胎种植率和临床妊娠率(P<0.01);移植多个胚胎提高胚胎种植率(P<0.05),但子宫内膜厚度>12 mm提高临床妊娠率(P<0.05)。多因素Logistic回归分析显示年龄增加和优胚移植数目减少是临床妊娠率的危险因素(P<0.01)。结论患者年龄和移植优胚数目是影响FET的主要因素;年龄增加是临床妊娠结局的危险因素。

Objective To investigate the factors in frozen-thawed embryo transfer(FET)cycles that affecting the pregnancy outcome.Methods The clinical data of 1169 couples who underwent FET in Shenzhen Maternity and Child Healthcare Hospital from January,2017 to December,2019 were retrospectively analyzed.Univariate analysis and Logistic multivariate regression analysis were performed to identify the factors which influence pregnancy outcome of FET cycles.Results The clinical pregnancy rate of 1169 FET cycles was 50.13%.Univariate analysis showed that female patients>35 years old or infertility duration>6 years significantly had a reduced embryo implantation rate and clinical pregnancy rate(P<0.01).But the embryo implantation rate and clinical pregnancy rate were increased by blastocyst or multiple embryos transfer(P<0.01).Multiple embryo transplantation increased embryo implantation rate(P<0.05)and endometrial thickness>12 mm increased clinical pregnancy rate(P<0.05).Logistic multivariat regression analysis showed that elder age and decreasing number of optimal embryo transplantation were risk factors for clinical pregnancy rate(P<0.01).Conclusions Patients age,embryo age and the number of transplanted embryos of high quality are the main factors affecting the pregnancy outcome of FET.Elder age is a risk factor for clinical pregnancy outcome.