视神经脊髓炎谱系疾病与妊娠

Neuromyelitis optica spectrum disorders and pregnancy

视神经脊髓炎谱系疾病是一种中枢神经系统自身免疫性疾病,好发于育龄期女性,可影响妊娠计划、生育能力,对妊娠结局的影响尚不明确;妊娠可引起免疫系统和性激素水平变化,造成疾病复发和进展。合理的免疫抑制治疗可以有效避免妊娠相关疾病活动。妊娠期和分娩后应用小剂量糖皮质激素、硫唑嘌呤和利妥昔单抗可能是安全的。

Neuromyelitis optica spectrum diseases(NMOSDs)is an autoimmune disease of central nervous system,which occurs frequently in women of childbearing age.NMOSDs may affect pregnancy planning and fertility,and the effect on pregnancy outcome is not clear.Pregnancy can cause changes in the immune system and sex hormone levels,which results in NMOSDs recurrence and progression.Reasonable immunosuppressive treatment may effectively avoid pregnancy-related disease activities using low-dose corticosteroids,azathioprine and rituximab may be safe during pregnancy and after delivery.