冠状动脉粥样硬化性心脏病患者血清SFRP5、FGF21、IGF-I水平与血脂和冠状动脉病变严重程度的相关性研究

Correlation Study of Serum SFRP5,FGF21,IGF-I Levels and Blood Lipids and Severity of Coronary Artery Disease in Patients with Coronary Atherosclerotic Heart Disease

目的:探讨冠状动脉粥样硬化性心脏病(CHD)患者血清分泌型卷曲蛋白5(SFRP5)、成纤维细胞生长因子21(FGF21)、胰岛素样生长因子-1(IGF-I)水平与血脂和冠状动脉病变严重程度的相关性。方法:选择2018年6月至2021年6月我院收治的109例CHD患者(CHD组),根据冠心病类型分为稳定型心绞痛组(SAP组,32例),不稳定型心绞痛组(UA组,42例)、急性心肌梗死组(AMI组,35例),根据Gensini积分分为轻度病变组(≤20分,42例)、中度病变组(21~40分,44例)和重度病变组(>40分,23例),另选择同期在我院行冠脉造影检查结果为正常的53例患者为对照组。检测并比较各组血清SFRP5、FGF21、IGF-I、血脂水平,分析血清SFRP5、FGF21、IGF-I与血脂和Gensini积分的相关性。结果:不同类型、不同冠脉病变程度CHD患者的血清SFRP5、FGF21、IGF-I、HDL-C水平均低于对照组,血清TC、TG、LDL-C水平均高于对照组,差异有统计学意义(P<0.05);血清SFRP5、FGF21、IGF-I水平的差异比较中,UA组低于SAP组,AMI组又低于UA组,中度病变组低于轻度病变组,重度病变组又低于中度病变组,差异均有统计学意义(P<0.05);血清TC、LDL-C水平的差异比较中,UA组高于SAP组,AMI组又高于UA组,中度病变组高于轻度病变组,重度病变组又高于中度病变组,差异均有统计学意义(P<0.05);而SAP组、UA组、AMI组之间两两比较以及轻度病变组、中度病变组、重度病变组之间两两比较的血清TG、HDL-C水平差异无统计学意义(P>0.05)。Pearson相关性分析结果显示:血清SFRP5、FGF21、IGF-I水平与TC、LDL-C、Gensini积分呈负相关(P<0.05)。结论:CHD患者血清SFRP5、FGF21、IGF-I水平均降低,且与血脂水平增高以及CHD病变程度加重均有关。

Objective:To investigate the correlation between the levels of serum secreted curly protein 5(SFRP5),fibroblasts growth factor 21(FGF21)and insulin-like growth factor 1(IGF-I)and blood lipids and the severity of coronary artery disease in patients with coronary atherosclerotic heart disease(CHD).Methods:A total of 109 patients with CHD(CHD group)who were admitted to our hospital from June 2018 to June 2021 were selected.According to the types of CHD,they were divided into stable angina group(SAP group,32 cases),unstable angina group(UA group,42 cases)and acute myocardial infarction group(AMI group,35 cases).According to Gensini score,they were divided into mild lesion group(≤20 scores,42 cases),moderate lesion group(21~40 scores,44 cases)and severe lesion group(>40 scores,23 cases).53 patients with normal results of coronary angiography in our hospital at the same time were selected as the control group.Serum SFRP5,FGF21,IGF-I and blood lipid levels were detected and compared in each group,and the correlation between serum SFRP5,FGF21,IGF-I and blood lipids and Gensini score were analyzed.Results:The serum SFRP5,FGF21,IGF-I and HDL-C levels in patients with CHD with different types and degrees of coronary artery disease were lower than those in the control group,while the serum TC,TG and LDL-C levels were higher than those in the control group,the differences were statistically significant(P<0.05).The differences comparison of serum SFRP5,FGF21 and IGF-I levels showed that UA group was lower than SAP group,AMI group was lower than UA group,moderate lesion group was lower than mild lesion group,and severe lesion group was lower than moderate lesion group,the differences were statistically significant(P<0.05).The differences comparison of serum TC and LDL-C levels showed that UA group was higher than SAP group,AMI group was higher than UA group,moderate lesion group was higher than mild lesion group,and severe lesion group was higher than moderate lesion group,the differences were statistically significant(P<0.05).There were no significant differences in serum TG and HDL-C levels between SAP group,UA group and AMI group,as well as between mild lesions group,moderate lesions group and severe lesions group(P>0.05).Pearson correlation analysis showed that serum SFRP5,FGF21 and IGF-I levels were negatively correlated with TC,LDL-C and Gensini score(P<0.05).Conclusion:The serum SFRP5,FGF21 and IGF-I levels in patients with CHD are decreased,which are related to the increase of blood lipids level and the aggravation of CHD lesions.