神经导航辅助神经内镜经鼻蝶垂体瘤切除术治疗垂体瘤患者的临床疗效

Clinical efficacy of neuronavigation-assisted neuroendoscopic transsphenoidal pituitary adenoma resection in patients with pituitary adenoma

目的探讨神经导航辅助神经内镜经鼻蝶垂体瘤切除术治疗垂体瘤患者的临床疗效。方法以湘南学院附属医院2018年6月至2020年6月期间收治的90例垂体瘤患者作为研究对象,采用随机数字表法将患者分为对照组与观察组,每组各45例,对照组患者予以显微镜下经鼻蝶垂体瘤切除术进行治疗,观察组患者予以神经导航辅助神经内镜经鼻蝶垂体瘤切除术进行治疗,比较两组患者的手术结局、内分泌激素情况及并发症发生情况。结果术后,观察组患者手术时间显著长于对照组,差异有统计学意义(P<0.05)。观察组患者术中出血量显著少于对照组,住院时间显著短于对照组,差异有统计学意义(P<0.05)。观察组患者促甲状腺激素水平、游离三碘甲状腺原氨酶水平、游离甲状腺素水平均显著高于对照组,差异有统计学意义(P<0.05)。观察组患者的并发症总发生率为8.88%,显著低于对照组的24.44%,差异有统计学意义(P<0.05)。结论应用神经导航辅助神经内镜经鼻蝶垂体瘤切除术治疗垂体瘤患者,可获得更好的手术结局及内分泌激素水平,降低并发症发生率。

Objective To explore the clinical efficacy of neuronavigation-assisted neuroendoscopic transsphenoidal pituitary adenoma resection in patients with pituitary adenoma.Methods Ninety patients with pituitary adenoma admitted to Affiliated Hospital of Xiangnan University from June 2018 to June 2020 were selected as the study subjects and divided into control group(n=45)and observation group(n=45)using the random number table method.The patients in the control group were treated with microscopic transsphenoidal pituitary adenoma resection,and the patients in the observation group were treated with neuronavigation-assisted neuroendoscopic transsphenoidal pituitary adenoma resection.The surgical outcomes,endocrine hormones,and complications were compared between the two groups.Results After the operation,the operation time of the observation group was significantly longer than that of the control group,and the difference had statistical significance(P<0.05).The intraoperative blood loss in the observation group was significantly less than in the control group,and the total hospital stay was significantly longer than that in the control group.The differences had statistical significance(P<0.05).The thyroid-stimulating hormone level,free triiodothyronine aminase level,and free thyroxine level in the observation group were significantly higher than those in the control group,and the differences had statistical significance(P<0.05).The incidence rate of complications in the observation group was 8.88%,which was significantly lower than 24.44%in the control group,and the difference had statistical significance(P<0.05).Conclusion Neuronavigation-assisted neuroendoscopic transsphenoidal pituitary adenoma resection in patients with pituitary adenoma can obtain better surgical outcomes and endocrine hormone levels and reduce the incidence of complications.