预防性肝动脉灌注化疗对胰腺癌术后长期生存的影响

Effect of preventive hepatic arterial infusion chemotherapy on long-term survival after pancreatic cancer surgery

目的探讨预防性肝动脉灌注化疗(HAIC)对胰腺癌(PC)术后长期生存的影响。方法收集2010年6月至2015年5月间在湖州师范学院附属第一医院接受手术切除的87例PC患者资料。根据术后辅助化疗模式,将患者分为HAIC组(n=43)和对照组(n=44)。HAIC组术后接受2个周期HAIC和4个周期静脉化疗,对照组接受6个疗程静脉化疗。观察两组长期生存情况及化疗毒性。结果HAIC组5年总生存率为25.58%,对照组为18.18%,HAIC组显著高于对照组(P<0.05)。两组的毒副作用比较,差异无统计学意义(P>0.05),无化疗相关死亡发生。结论预防性肝动脉灌注化疗可显著改善胰腺癌术后患者长期生存,且安全性好。

Objective To investigate the effect of preventive hepatic arterial infusion chemotherapy(HAIC)on long-term survival after pancreatic cancer(PC)surgery.Methods The data of 87 PC patients who underwent surgical resection in the First Affiliated Hospital of Huzhou Teachers College from June 2010 to May 2015 were collected.They were divided into the HAIC group(43 patients)and the control group(44 patients),according to the mode of postoperative adjuvant chemotherapy.The HAIC group were given 2 courses of HAIC and 4 courses of intravenous chemotherapy after surgery,and the control group were given 6 courses of intravenous chemotherapy.The long-term survival and chemotherapy toxicity were observed and compared between the two groups.Results The 5-year overall survival rate of the HAIC group was 25.58%,which was significantly higher than that of the control group as 18.18%(P<0.05).There were no significant differences in toxicity and side effects between the two groups(P>0.05).There were no chemotherapy-related deaths occurred.Conclusion Preventive hepatic artery infusion chemotherapy can significantly improve the long-term survival of patients with pancreatic cancer after surgery,with good safety.