角膜胶原交联术及其联合屈光手术治疗圆锥角膜研究进展

Research Progress on Corneal Collagen Cross-Linking and Its Combination with Refractive Surgery for Keratoconus

自90年代末以来,角膜胶原交联术(CXL)已成为治疗圆锥角膜的首选治疗方式。如今,CXL与屈光矫正术的结合(CXL plus)受到更多关注。CXL plus在阻止圆锥角膜进展的同时,也为患者的视觉康复提供了新途径。现有多种联合方案且均已得到不同程度的研究,包括准分子激光屈光性角膜消融术、准分子激光治疗性角膜消融术、角膜基质内环植入及有晶状体眼人工晶状体植入等。本综述旨在介绍目前常用的CXL及CXL plus的研究现状,并讨论这些方案的潜力。

Corneal collagen cross-linking(CXL)has become the preferred modality of treatment for progressive keratoconus since the late 1990s.There has been an increasing appeal for a completely surgical approach by combining CXL with adjuvant refractive procedures both to halt the ectatic process and enhance functional visual outcomes.Several combined protocols have been studied to various degrees in conjunction with CXL,involving photorefractive keratectomy,transepithelial phototherapeutic keratectomy,intrastromal corneal ring segments implantation,and phakic intraocular lens implantation.This review summarizes current CXL protocols,presents the current status of studies involving CXL plus and discusses the future potential of these protocols.