基于CiteSpace的CYP1B1研究现状及发展趋势分析

Analysis of the Research Status and Development Trend of CYP1B1 Based on CiteSpace

目的分析CYP1B1的研究现状及发展趋势。方法使用CiteSpace5.8.R1软件对Web of Science核心数据库中1994年1月1日-2021年6月30日CYP1B1相关文献的作者及研究机构进行合作网络分析。结果共纳入2374篇有关CYP1B1的文献,1994-2020年发文量呈稳步增长趋势,但也存在一定程度的波动,平均年发文量为86篇。发文作者共有977位,发文量前3位的作者分别为Colin R.Jefcoate、Frank J.Gonzalez和Ayman O.S.El-Kadi,发文量分别是52、41、27篇。发文机构共368个单位,主要为医学类研究所及医学院校,发文量前3位的机构分别为National Cancer Institute、University of Wisconsin和Vanderbilt University Medical School。机构与作者呈现“抱团”现象。发文关键词共312个,肺癌是中介中心性最高的关键词,中介中心性为0.47,频数为124。共得到5个关键词聚类,分别为#0 induction、#01 CYP1B1、#02 primary congenital glaucoma、#03 CYP1A1、#04 inflammation。氧化应激、炎症、暴露、通路、表型和青光眼仍是现在研究关键词。结论CYP1B1相关文献逐年增加,但发文机构及作者之间缺乏合作与交流;CYP1B1相关的氧化应激病理机制研究是未来的发展趋势和研究热点。

Objective To analyze the research status and development trend of CYP1B1.Methods CiteSpace5.8.R1 software was used to analyze the cooperative network of authors and research institutions related to CYP1B1 in the core database of Web of Science from January 1,1994 to June 30,2021.Results A total of 2374 articles about CYP1B1 were included.The number of articles published from 1994 to 2020 showed a steady growth trend,but there were also some fluctuations,with an average annual number of 86 articles.There were a total of 977 authors,and the top three authors in the number of published papers were Colin R.Jefcoate,Frank J.Gonzalez and Ayman O.S.El-Kadi,and the number of published papers was 52,41 and 27.There were a total of 368 institutions,mainly medical institutes and medical colleges,and the top three institutions with the largest number of papers were the National Cancer Institute,the University of Wisconsin and Vanderbilt University Medical School.Institutions and authors were presented the“group”phenomenon.A total of 312 key words were published,lung cancer was the highest intermediary centrality keyword with an intermediary centrality of 0.47 and a frequency of 124.A total of 5 keywords were obtained,which were#0 induction,#01 CYP1B1,#02 primary congenital glaucoma,#03 CYP1A1,#04 inflammation.Oxidative stress,inflammation,exposure,pathway,phenotype and glaucoma were still the key words in the current study.Conclusion The literature on CYP1B1 is increasing year by year,but there is a lack of cooperation and communication between publishers and authors.The pathological mechanism of oxidative stress related to CYP1B1 is the future development trend and research hotspot.