布地奈德联合西替利嗪治疗小儿哮喘对患儿 呼吸功能及免疫功能指标的影响

Effects of Budesonide Combined with Cetirizine on Respiratory Function and Immune Function in Children with Asthma

目的分析布地奈德联合西替利嗪治疗小儿哮喘对呼吸功能及免疫功能指标的影响。方法选择2018年1月-2021年5月张家港市第一人民医院儿科收治的小儿哮喘患者120例,采用随机数字表法分为对照组和观察组,各60例。对照组给予布地奈德治疗,观察组在对照组基础上加用西替利嗪治疗,比较两组临床疗效、治疗前后肺功能指标、免疫功能指标及不良反应发生率。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05);两组FVC、FEV1、MMF及MVV均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组IgA低于对照组,IgG、IgM及IgE高于对照组,差异有统计学意义(P<0.05);两组嗜睡、腹痛腹泻、心率减缓、口干及头晕的发生率比较,差异无统计学意义(P>0.05)。结论布地奈德联合西替利嗪治疗小儿哮喘有助于缓解临床症状及体征,改善肺功能及免疫指标,且治疗期间无明显不良反应,安全性较好。

Objective To analyze the effect of budesonide combined with cetirizine on respiratory function and immune function in children with asthma.Methods A total of 120 children with asthma admitted to the Department of Pediatrics of Zhangjiagang First People's Hospital from January 2018 to May 2021 were selected and randomly divided into control group and observation group,with 60 cases in each group.The control group was treated with budesonide,and the observation group was treated with cetirizine on the basis of the control group.The clinical efficacy,pulmonary function indexes before and after treatment,immune function indexes and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).FVC,FEV1,MMF and MVV in the two groups were higher than those before treatment,and those in the observation group were higher than the control group,the difference was statistically significant(P<0.05).IgA in the observation group was lower than that in the control group,IgG,IgM and IgE were higher than those in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of lethargy,abdominal pain and diarrhea,heart rate slowing,dry mouth and dizziness between the two groups(P>0.05).Conclusion Budesonide combined with cetirizine in the treatment of asthma in children is helpful to alleviate clinical symptoms and signs,improve lung function and immune indexes,and there is no obvious adverse reaction during treatment,with good safety.