腹腔镜结肠癌根治术与传统开腹手术治疗效果的比较

Comparison of Therapeutic Effects Between Laparoscopic Colon Cancer Radical Operation and Traditional Laparotomy Operation

目的比较腹腔镜结肠癌根治术与传统开腹手术的效果。方法选取2016年1月-2020年12月在我院诊治的76例结肠癌患者为研究对象,采用随机数字表法分为对照组和观察组,各38例。对照组采用传统开腹手术治疗,观察组采用腹腔镜结肠癌根治术治疗,比较两组临床手术指标、血清肿瘤标志物、并发症发生率以及远期疗效。结果观察组手术时间、术中出血量、胃肠功能恢复时间、住院时间均小于对照组,差异有统计学意义(P<0.05);两组淋巴结清除数比较,差异无统计学意义(P>0.05);术后,两组血清肿瘤标志物CEA、CA199、CA125水平均低于术前,差异有统计学意义(P<0.05),但观察组与对照组比较,差异无统计学意义(P>0.05);观察组并发症发生率为7.89%,低于对照组的18.42%,差异有统计学意义(P<0.05);随访6个月,观察组局部复发率为5.26%、远端转移率为7.89%,与对照组的7.89%、10.53%比较,差异无统计学意义(P>0.05)。结论在肿瘤切除、血清肿瘤标志物水平、远期疗效方面腹腔镜根治术治疗结肠癌可获得与传统开腹手术基本一致的手术效果,且可缩短手术时间、术后恢复时间,减少术中出血量,降低并发症发生率,具有显著的应用优势,值得临床应用。

Objective To compare the clinical effects of laparoscopic colon cancer radical operation and traditional laparotomy operation.Methods A total of 76 patients with colon cancer who were treated in our hospital from January 2016 to December 2020 were selected as the research objects.They were divided into control group and observation group by random number table method,with 38 cases in each group.The control group was treated with traditional laparotomy operation,and the observation group was treated with laparoscopic colon cancer radical operation.The clinical indexes,serum tumor markers,incidence of complications and long-term efficacy were compared between the two groups.Results The operation time,intraoperative blood loss,gastrointestinal function recovery time and hospitalization time of the observation group were less than those of the control group,and the difference was statistically significant(P<0.05);there was no significant difference in the number of lymph node clearance between the two groups(P>0.05).After operation,the levels of serum tumor markers CEA,CA199 and CA125 in the two groups were lower than those before operation,and the difference was statistically significant(P<0.05),while there was no significant difference between the observation group and the control group(P>0.05).The incidence of complications in the observation group was 7.89%,which was lower than 18.42%in the control group,and the difference was statistically significant(P<0.05).After 6 months of follow-up,the local recurrence rate was 5.26%and the distal metastasis rate was 7.89%in the observation group,which were compared with 7.89%and 10.53%in the control group,the difference was not statistically significant(P>0.05).Conclusion Laparoscopic colon cancer radical operation can achieve the same results as traditional laparotomy operation in terms of tumor resection,serum tumor markers and long-term outcome,and can shorten the operation time and postoperative recovery time,reduce the amount of intraoperative bleeding and the incidence of complications,has a significant application advantages,which is worth clinical application.