双歧三联活菌联合西替利嗪治疗小儿湿疹及对其免疫球蛋白水平的影响

Effect of Bifid Triple Viable Combined with Cetirizine on Immunoglobulin Levels in Children with Atopic Dermatitis

目的研究双歧三联活菌联合西替利嗪治疗小儿湿疹(AD)对其免疫球蛋白水平的影响。方法选取2020年4月-2021年4月佳木斯市中心医院儿科接诊的78例AD患儿,采用随机数字表法分为对照组与观察组,各39例。对照组给予西替利嗪治疗,观察组在其基础上联合双歧三联活菌治疗,比较两组临床疗效、肠道菌群数量、炎性因子及免疫球蛋白水平。结果观察组治疗有效率为87.18%,高于对照组的71.79%,差异有统计学意义(P<0.05);观察组双歧杆菌及乳杆菌数量高于治疗前,大肠埃希菌数量低于治疗前,差异有统计学意义(P<0.05);两组IL-4、IL-10、IgG、IgM均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论双歧三联活菌联合西替利嗪治疗AD疗效确切,可改善患儿肠道菌群,减轻机体炎性反应,提高其免疫功能。

Objective To study the effect of bifid triple viable combined with cetirizine on immunoglobulin levels in children with atopic dermatitis(AD).Methods A total of 78 children with AD admitted to Jiamusi Central Hospital from April 2020 to April 2021 were selected and randomly divided into control group and observation group,with 39 cases in each group.The control group was treated with cetirizine,and the observation group was treated with bifid triple viable bacteria on the basis of cetirizine.The clinical efficacy,intestinal flora,inflammatory factors and immunoglobulin levels were compared between the two groups.Results The effective rate of the observation group was 87.18%,which was higher than 71.79%of the control group,and the difference was statistically significant(P<0.05).The number of Bifidobacterium and Lactobacillus in the observation group was higher than that before treatment,and the number of Escherichia coli was lower than that before treatment,the difference was statistically significant(P<0.05).The levels of IL-4,IL-10,IgG and IgM in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group,with significant difference(P<0.05).Conclusion The combination of bifidus triple viable bacteria combined with cetirizine has a definite effect in the treatment of AD,which can improve the intestinal flora of children,reduce the body's inflammatory response,and improve their immune function.