纤溶酶对脑卒中患者残疾功能的疗效

Effect of Fibrinolytic Enzyme on Disability Function in Stroke Patients

目的观察纤溶酶治疗脑卒中患者残疾功能的疗效。方法选取2018年1月-2021年1月在我院诊治的104例脑卒中患者为研究对象,采用随机数字表法分为对照组和观察组,各52例。对照组给予常规治疗,观察组在对照组基础上给予纤溶酶治疗。比较两组临床疗效、神经功能缺损(NIHSS)评分、凝血功能指标、运动功能评分以及临床不良反应发生情况。结果两组患者神经功能缺损评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组PT、APTT均高于治疗前,FIB、DDI均低于治疗前,且观察组PT、APTT高于对照组,FIB、DDI低于对照组,差异有统计学意义(P<0.05);两组运动功能评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率高于对照组(96.15%vs 82.69%),差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组(5.77%vs 7.69%),但差异无统计学意义(P>0.05)。结论纤溶酶治疗脑卒中患者残疾功能效果确切,可提高临床治疗总有效率,降低神经功能缺损评分,改善凝血功能指标和运动功能,且不良反应少。

Objective To observe the effect of fibrinolytic enzyme on disability function in stroke patients.Methods A total of 104 stroke patients who were treated in our hospital from January 2018 to January 2021 were selected as the research objects.They were divided into control group and observation group by random number table method,with 52 cases in each group.The control group was given conventional treatment,and the observation group was given fibrinolytic enzyme treatment on the basis of the control group.The clinical efficacy,NIHSS score,coagulation function index,motor function score and clinical adverse reactions were compared between the two groups.Results After treatment,the neurological deficit scores of the two groups were lower than those before treatment,and those of the observation group were lower than the control group,the difference was statistically significant(P<0.05).After treatment,PT and APTT in the two groups were higher than those before treatment,FIB and DDI were lower than those before treatment,and PT and APTT in the observation group were higher than those in the control group,FIB and DDI were lower than those in the control group,the difference was statistically significant(P<0.05).After treatment,the motor function scores of the two groups were higher than those before treatment,and those of the observation group was higher than the control group,the difference was statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group(96.15%vs 82.69%),and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(5.77%vs 7.69%),but the difference was not statistically significant(P>0.05).Conclusion Fibrinolytic therapy can effectively treat the disability function of stroke patients,improve the total effective rate of clinical treatment,reduce the neurological deficit score,improve coagulation function and motor function,and has less adverse reactions.