基于改良科赫法则探讨炎性肠病微生态失调及微生物治疗策略

Discussion on Dysbiosis in Inflammatory Bowel Disease and Microbial Treatment Strategy Based on Modified Koch′s Postulates

炎性肠病(IBD)是发生于肠道的慢性非特异性炎症,其发病与多种因素相关。其中,微生态失调与IBD密切相关,但具体机制目前尚未完全阐明。随着现代医学的发展,传统的科赫法则已不再适用于所有感染性疾病的病因学研究。“生态”科赫法则和“共生微生物”科赫法则是对传统科赫法则的改良,其中“生态”科赫法将单一致病原扩展至肠道微生态系统,为阐明IBD病因提供了更全面的证据,而“共生微生物”为重建IBD患者肠道微生态平衡提供了新的治疗思路。基于改良科赫法则探讨更加复杂的现代疾病,将有助于从整体水平阐明疾病病因并提高治疗策略的针对性。

Inflammatory bowel disease(IBD)is a chronic nonspecific inflammation of the intestine,the onset of which is related to many factors.There is a complex and close relationship between microecological imbalance and IBD,but its specific mechanism has not been fully clarified.With the development of modern medicine,it is found that the traditional Koch′s postulates is no longer applicable to the etiology of all infectious diseases.The"ecological"Koch′s postulates and the"commensal"Koch′s postulates are two kinds of the modified Koch′s postulates.The former extends the single pathogenic agent to the intestinal microecosystem,which provides more comprehensive evidence for clarifying the etiology of IBD.The latter provides a therapeutic idea for reconstructing the intestinal microecological balance in IBD patients.When facing complex modern diseases,discussions based on modified Koch′s postulates will help us to clarify the etiology and improve the pertinence of treatment strategies at a holistic level.