疏肝健脾法治疗原发性高血压的研究进展

Research Progress in Treatment of Essential Hypertension by Soothing Liver and Invigorating Spleen

高血压作为最常见的心血管疾病,如果不严格控制,很容易对心、脑、肾等重要靶器官造成损害。肝郁、脾虚是导致高血压疾病的重要病机,从肝、脾着手,顺应肝脾五行属性与两者之间的生克、乘侮关系,辨证施治,以疏肝、健脾两个角度为切入点,进行药物化裁加减治疗能取得较好的效果。其作用机制可能与减轻小动脉痉挛、降低血液黏度、改善微循环、抑制肾素-血管紧张素-醛固酮系统活性、降低细胞因子水平、抑制血管活性物质的生成、传递及表达等相关,这不仅为“从肝脾论治高血压”提供了依据,也为高血压药物的研究开发提供了新思路。

As the most common cardiovascular disease,hypertension,if not strictly controlled,is likely to cause damage to the heart,brain,kidney and other important target organs.Liver depression and spleen deficiency are important pathogenesis of hypertension.Starting from the liver and spleen,following the five elements of the liver and spleen and the relationship of generation and restriction,subjugation and counterrestriction between them,treating with differentiation of symptoms and signs,cutting in from the points of soothing the liver and strengthening the spleen,through addition and subtraction of the medications,better results can be achieved.The mechanism may be related to relieving the small artery spasm,reducing the blood viscosity,improving microcirculation,inhibiting renin-angiotensin-aldosterone system activity,lowering levels of cytokines,inhibiting the generation,transfer and expression of vascular active substances,etc.,which not only provides the basis for"treatment of hypertension from liver and spleen",but also provides a new train of thought for the drug research and development of hypertension.