经鞘内镇痛系统按需注射吗啡治疗癌性疼痛的效果观察

Efficacy of on-demand intrathecal injection of morphine for cancer pain

目的探讨癌性疼痛患者经鞘内镇痛系统按需注射吗啡治疗癌性疼痛的效果。方法选取2018年5月至2020年5月间盘锦市辽油宝石花医院收治的120例癌性疼痛患者,依照患者采用镇痛方式的不同将患者分为对照组和研究组,每组60例。对照组采用硬膜外注射吗啡镇痛治疗,研究组采用经鞘内镇痛系统按需注射吗啡镇痛治疗,对比两组临床治疗与镇痛效果。结果研究组患者镇痛起效时间低于对照组,差异有统计学意义(P <0.05);研究组患者镇痛后1周、3周、6周视觉模拟评分(VAS)低于对照组,差异有统计学意义(P <0.05)。对照组患者并发症发生率为11.7%(7/60)低于对照组1.7%(1/60),差异有统计学意义(P <0.05)。研究组患者镇痛后1周、3周、6周生活量表评分均高于对照组,差异均有统计学意义(均P <0.05)。结论经鞘内镇痛系统按需注射吗啡治疗癌性疼痛效果显著,患者经过镇痛治疗后疼痛明显好转,且不良反应发生率低,患者生活质量提高,适于临床推广。

Objective To investigate the efficacy of on-demand intrathecal injection of morphine for cancer pain. Methods One hundred and twenty patients with cancer pain who were hospitalized at Liaohe Oilfield Gem Flower Hospital were selected from May 2018 to May 2020. According to the different methods of analgesia adopted by the patients,the patients were divided into an experimental group and a control group with 60 patients in each group. The experimental group received on-demand intrathecal injection of morphine for cancer pain and the control group received epidural morphine for analgesia. The clinical treatment and analgesic efficacy were compared between the two groups. Results The analgesic onset time of patients was significantly lower in the experimental group than in the control group(P < 0. 05). The visual analogue scale(VAS) scores were significantly lower in patients in the experimental group than in the control group at one,three and six weeks after analgesia(all P < 0. 05). The incidence of complications was 11. 7%(7/60) in the experimental group,which was significantly lower than 1. 7%(1/60) of the control group(P < 0. 05). The quality of life scale(QOLS) life scale scores were significantly higher in the experimental group than in the control group at one,three and six weeks after analgesia(all P < 0. 05).Conclusion Intrathecal on-demand injection of morphine for cancer pain shows a significant effect. After analgesia treatment,pain is significantly relieved,the incidence of adverse reactions is reduced,and the quality of life is improved. It deserves clinical application.