摘要
RNA-dependent RNA polymerase(RdRp),also known as nsp12,is a key comp on ent in the syn thesis of viral ribonucleic acid(RNA)and is considered the primary target of nucleoside analog(NA)inhibitors.A recent publication by Kabinger et al.reported the unique molecular mechanisms of molnupiravir on inducing RNA mutations by RdRp during replication of SARS-CoV-2.^(1) As an oral broad-spectrum NA an tiviral age nt,moln upiravir has bee n prove n with considerable potential for the prevention and treatment of Corona Virus Disease 2019(COVID-19)(Fig.1).^(2)
基金
This work was supported by the grants from the NSFC(Nos.81773890,21772131,82073997)
the Fundamental Research Funds of Science&Technology Department of Sichuan Province(No.2021YFS0044)
Project First-Class Disciplines Development supported by CDUTCM.
