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Acquired cancer tyrosine kinase inhibitor resistance: ROS as critical determinants

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摘要 The ability of a minority of cancer cells lineages to withstand drug-induced toxicity and re-enter cell cycling in the presence of the drug has been observed for long,but the underlying mechanisms remained elusive.New work published in Nature by Oren and colleagues used barcode lentiviral library labeling to prominently discern antioxidant profiles,among others,being the primary underlying cellular program that governs proliferation under tyrosine kinase inhibitor(TKI)drug pressure.^(1)
机构地区 ZIK plasmatis
出处 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2022年第1期17-18,共2页 信号转导与靶向治疗(英文)
基金 Open Access funding enabled and organized by Projekt DEAL.
关键词 CANCER DRUG CYCLING
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