摘要
Dear Editor,Pathological neo-vascularization is a hallmark of cancer and several diseases.Accumulating evidence supports the notion that antiangiogenic treatment can abolish tumor angiogenesis to achieve Ion ger disease-free survival.Although growth factors and their receptors function as the main drivers in angiogenesis,the involvement of other regulators,e.g.,Cyclooxygenase-2(COX2),^(1) should also be con sidered,especially for managi ng the resista nee to therapies against receptor tyrosine kinases(RTKs).
基金
This study was supported by the National Natural Science Foundation of China(81773219)
National Basic Research Program of China(2015CB553906)
the PKU-Baidu Fund(2019BD015).
