具核梭杆菌促进结直肠癌发生发展机制研究进展

Research progress in mechanism of Fusobacterium nucleatum promoting colorectal cancer

具核梭杆菌(Fusobacterium nucleatum)是一种人体共生菌,尤其富集于口腔,在特定情况下可导致机会感染。近年来,随着微生物群与健康或疾病相关性研究的深入,具核梭杆菌与结直肠癌(colorectal cancer,CRC)之间的关联性研究备受关注。大量临床研究表明,具核梭杆菌在CRC中更为富集,且进一步的动物研究证明具核梭杆菌能够通过多种机制促进CRC的发生发展以及肿瘤耐药。本文对具核梭杆菌与CRC的关联性以及其对CRC的发生发展机制进行综述。

Fusobacterium nucleatum,a commensal bacterium in human oral cavity could cause opportunistic infections in certain conditions.Recently,the relationship between Fusobacterium nucleatum and colorectal cancer(CRC)has become a research focus.Clinical studies revealed that Fusobacterium nucleatum is implicated in CRC.Further studies on animals have proved that Fusobacterium nucleatum can promote the onset and progression of CRC and chemoresistance to treatments.This paper summarizes evidence for the association of Fusobacterium nucleatum with CRC and provides a comprehensive view of current mechanisms for the association.