摘要
Catalytic enantioselective ring-opening of oxa-and aza-bicyclic alkenes with readily available accessible alkenylboronic acids,promoted by a chiral phosphine-Co complex,is reported.Such a process represents the unprecedented Co-catalyzed introduction of various alkenyl groups onto the oxa-and aza-bicyclic alkenes,affording a wide range of multisubstituted functionalized cyclohexenes in up to 98%yield and 99.5:0.5 er.
基金
This work was financially supported by the National Natural Science Foundation of China(Grant Nos.21702222,92056103,21821002,21404118)
the Shanghai Rising-Star Program(Grant No.19QA1411000).