Construction of Chiral All-Carbon Quaternary Stereocenters by Asymmetric Friedel-Crafts Reaction of Isatin Derivatives

Un der the catalysis of chiral Cu(ll)complex,C2 and C3 alkylati on of pyrrole and C3 alkylation of in dole were realized simulta neously.The chiral oxindole skeleton with an all-carb on quater nary stereogenic cen ter at the C3-position could be obtai ned exclusively with high yields(up to 95%)and excellent enantioselectivities(up to>99%).