肝星状细胞活化相关信号通路在肝纤维化中的研究进展

Research progress of hepatic stellate cell activation-related signal pathways in liver fibrosis

肝纤维化是多种慢性肝损伤造成的细胞外基质(extracellular matrix, ECM)过度累积及降解不足的病理结果,如不加以干预会逐渐进展为肝硬化,甚至肝细胞癌。肝星状细胞(hepatic stellate cell, HSC)是ECM的主要来源,并且HSC在肝纤维化的起始、发展和消退过程中发挥关键作用。近年来,HSC活化涉及的信号传导通路成为研究热点,本文总结了HSC活化过程中的重要信号通路。

Liver fibrosis is the pathological result of excessive accumulation and insufficient degradation of extracellular matrix(ECM) caused by various chronic liver injuries. Without intervention, it will gradually progress to liver cirrhosis and even hepatocellular carcinoma over time. Hepatic stellate cell(HSC) is the main source of ECM, and it plays a key role in the initiation, development and regression of liver fibrosis. In recent years, the signal transduction pathway involved in HSC activation has become a research hotspot. This article summarized the important signal pathways in the HSC activation process.