α7-烟碱乙酰胆碱受体在肺癌发生、发展及治疗中的作用

Role ofα7-nicotinic Acetylcholine Receptor in Occurrence,Development and Therapy of Lung Cancer

烟碱乙酰胆碱受体(nAChRs)作为兴奋性和抑制性神经递质的中央调节器,控制癌细胞、癌微环境和远处转移生长因子、血管生成因子和神经营养因子的合成和释放。吸烟和其他潜在的不良环境和生活方式等因素上调nAChRs促癌作用并下调其抑癌作用。其中,α7-nAChR在肺癌细胞中高表达,并参与癌细胞的增殖、凋亡和迁移,有望成为肺癌治疗的一个新型靶点。

Nicotinic acetylcholine receptors(nAChRs)are the central regulators of stimulatory and inhibitory neurotransmitters that control the synthesis and release of growth,angiogenic and neurotrophic factors incancer cells,the cancer microenvironment and distantmetastasis.Smoking and other possibly environmental and lifestyle factors increase the function of nAChRs that up-regulates carcinogenesis and down-regulates carcinostasis.α7-nAChRis particularly overexpressed in lung cancer cells,and participates in the proliferation,apoptosis and migration of cancer cells.Thus,α7-nAChR might be a new therapeutic target for lung cancer.