miR-21、miR-125b与舌鳞状细胞癌患者预后生存的关系

Kaplan-Meier Analysis of Prognostic Value of miR-21 and miR-125b in Patients with Tongue Squamous Cell Carcinoma

目的研究miR-21、miR-125b与舌鳞状细胞癌患者预后生存的关系。方法选取86例舌鳞状细胞癌患者手术切除的癌组织与对应的癌旁正常组织,分别测定其组织中miR-21、miR-125b表达量。患者随访半年,分析miR-21、miR125b表达与患者预后生存的关系。结果舌鳞状细胞癌组织中miR-21、miR125b表达量显著高于癌旁正常组织(P<0.05)。舌鳞状细胞癌组织中miR-21、miR125b表达与患者性别、年龄无关(P>0.05),与组织分化程度、颈淋巴转移和临床分期有关(P<0.05)。半年随访中,共17例患者死亡,69例存活。经Kaplan-Meier生存分析显示,miR-21与miR125b表达量越高患者生存率越低。经Cox比例风险回归模型分析显示,miR-21与miR125b高表达、发生颈淋巴结转移、临床分期在Ⅲ~Ⅳ期为舌鳞状细胞癌患者预后的影响因素(P<0.05)。结论舌鳞状细胞癌组织中miR-21、miR-125b呈高表达状态,且与组织分化程度、颈淋巴结转移和临床分期有关,为影响预后的危险因素,可作为临床预测患者预后生存的标志物。

Objective To investigate the prognostic value of miR-21 and miR-125 b in patients with tongue squamous cell carcinoma based on Kaplan-Meier analysis.Methods 86 cases of tongue squamous cell carcinoma were selected, and the expression levels of miR-21 and miR-125 b in surgically resected cancer tissues and adjacent normal tissues were detected respectively.Results The expression of miR-21 and miR125 b in tongue squamous cell carcinoma tissues was significantly higher than that in adjacent normal tissues(P<0.05).The expression of miR-21 and miR125 b in tongue squamous cell carcinoma was not related to gender and age(P>0.05),but was related to the degree of tissue differentiation, lymphatic metastasis and clinical stage(P<0.05).The half-year follow-up results showed that 17 patients died and 69 survived.Kaplan-Meier survival analysis showed that patients with high expression of miR-21 and miR125 b had low survival rate.Cox proportional hazard regression model analysis showed that elevated expression of miR-21 and miR125 b, cervical lymph node metastasis, and clinical stage of Ⅲ~Ⅳ were the prognostic factors of patients with tongue squamous cell carcinoma(P<0.05).Conclusion The expression of miR-21 and miR-125 b in tongue squamous cell carcinoma tissue is elevated, and related to the degree of tissue differentiation, cervical lymph node metastasis and clinical stage.The two indicators are risk factors that affect the prognosis, which can be used as clinical predictors of prognostic survival.