先天性神经母细胞瘤发病机制与临床特点的研究进展

Pathogenesis and clinical characteristics of congenital neuroblastoma

神经母细胞瘤是儿童最常见的颅外实体肿瘤,来源于肾上腺髓质或交感神经节。先天性神经母细胞瘤约占神经母细胞瘤患儿总数的5%,大多数患儿于出生后1个月内确诊。与1岁以上神经母细胞瘤患儿相比,新生儿神经母细胞瘤有其独特的病程。本文就先天性神经母细胞瘤的发病机制、临床表现、治疗方法以及预测患儿长期预后的生物学因素进行综述。

As the most common extracranial solid tumor in children,neuroblastoma originates from adrenal medulla or sympathetic ganglion.Congenital neuroblastoma accounts for 5% of all neuroblastomas and most patients are diagnosed within the first month after birth.Neonates have a unique disease course as compared to children aged over 1 year.This review summarized the pathogenesis and clinical presentations of congenital neuroblastoma,as well as biological factors of predicting the long-term prognosis of congenital neuroblastoma.