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氟西汀联合茴拉西坦治疗老年抑郁症疗效观察及对患者血清总胆汁酸、去甲肾上腺素水平的影响 被引量:6

Efficacy of combined fluoxetine and aniracetam tablets in the treatment of senile depression and its effects on serum total bile acid and norepinephrine levels
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摘要 目的探讨氟西汀联合茴拉西坦治疗老年抑郁症的疗效及对患者血清总胆汁酸(TBA)、去甲肾上腺素(NE)水平的影响。方法选取菏泽市精神卫生中心2019年1一12月收治的老年抑郁症患者100例为观察对象,采用随机数字表法分为对照组(n=50)、研究组(n=50)。对照组予氟西汀单药治疗,研究组予氟西汀联合茴拉西坦片治疗,两组疗程2个月。比较两组疗效、汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)评分、不良反应和血清TBA、NE水平。结果研究组总有效率为96.0%(48/50),显著高于对照组的84.0%)(42/50),差异有统计学意义(χ^(2)=4.00,P=0.045)。治疗后,研究组HAMD评分(5.85±1.81)分、HAMA评分(4.81±1.57)分,显著低于对照组的(11.65±2.65)分、(10.85±2.84)分,差异均有统计学意义(t=10.84,P<0.001;t=11.16,P<0.001);研究组血清NE为(138.68±16.35)ng/L,显著高于对照组的(127.17±14.34)ng/L(t=3.17,P=0.002);研究组血清TBA为(5.85±0.63)μmol/L,不良反应发生率为8.00%,与对照组[(5.91±0.65)μmol/L、6.00%]差异均无统计学意义(t=0.39,P=0.692;χ^(2)=0.15,P=0.695)。结论氟西汀联合茴拉西坦治疗老年抑郁症患者的效果明显,且安全性较高,不影响患者机体代谢功能,值得在临床上推广应用。 Objective To investigate the efficacy of combined fluoxetine and aniracetam tablets in the treatment of senile depression and its effects on serum total bile acid(TBA)and norepinephrine(NE)levels.Methods A total of 100 older adult patients with depression who received treatment in Heze Medical College from January 2019 to December 2019 were included in this study.They were randomly assigned to receive either fluoxetine tablets alone(control group,n=50)or fluoxetine and aniracetam tablets(study group,n=50).All patients received two months of treatment.Clinical efficacy,scores of the Hamilton Rating Scale for Anxiety(HAMA)and the Hamilton Rating Scale for Depression(HAMD),adverse reactions,and serum TBA and NE levels were compared between the two groups.Results Total response rate was significantly higher in the study group than in the control group[96.0%(48/50)vs.84.0%(42/50),χ^(2)=4.00,P=0.045].HAMD and HAMA scores post-treatment in the study group were(5.85±1.81)points and(4.81±1.57)points,respectively,which were significantly lower than those in the control group[(11.65±2.65)points,(10.85±2.84)points,t=10.84,P<0.001;t=11.16,P<0.001).Serum NE level was significantly higher in the study group than in the control group[(138.68±16.35)ng/L vs.(127.17±14.34)ng/L,t=3.17,P=0.002].There were no significant differences in serum TBA level[(5.85±0.63)μmol/L vs.(5.91±0.65)μmol/L]and the incidence of adverse reactions(8.00%vs.6.00%)between the study and control groups(t=0.39,P=0.692;χ^(2)=0.15,P=0.695).Conclusion The combined therapy of fluoxetine and aniracetam tablets for the treatment of senile depression is safe and highly effective,does not affect metabolic function and thereby deserves clinical application.
作者 刘英 袁继承 王国平 Liu Ying;Yuan Jicheng;Wang Guoping(Department of Nursing,Heze Medical College,Heze 274000,Shandong Province,China)
出处 《中国基层医药》 CAS 2022年第2期171-174,共4页 Chinese Journal of Primary Medicine and Pharmacy
关键词 氟西汀 茴拉西坦片 老年人 抑郁症 疗效 不良反应 汉密尔顿抑郁量表评分 汉密尔顿焦虑量表评分 Fluoxetine Aniracetam tablets Aged Depression Efficacy Adverse reactions Hamilton depression scale Hamilton anxiety scale
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