利奈唑胺治疗老年白血病患者化疗后伴革兰阳性球菌感染的疗效观察

Efficacy of linezolid in the treatment of gram-positive coccal infections after chemotherapy in older adult patients with leukemia

目的探究利奈唑胺治疗老年白血病患者化疗后伴革兰阳性(G+)球菌感染的临床疗效及不良反应。方法选取义乌市中心医院2017年1月至2019年12月治疗的老年白血病患者化疗后伴G+球菌感染92例为研究对象,采用随机数字表法分对照组(n=46,常规抗感染治疗)和观察组(n=46,利奈唑胺治疗),比较两组临床疗效、体温恢复时间、用药时间。结果观察组总有效率为95.65%(44/46),显著高于对照组的78.26%(36/46),差异有统计学意义(χ^(2)=6.13,P=0.013);观察组体温恢复正常时间、用药时间分别为(7.98±1.04)d、(8.58±1.31)d,均短于对照组的(8.85±1.47)d、(9.46±2.52)d,差异均有统计学意义(t=3.27、2.10,P=0.001、0.019);观察组不良反应发生率为4.35%(2/46),低于对照组的19.57%(9/46),两组差异有统计学意义(χ^(2)=5.05,P<0.05)。结论应用利奈唑胺治疗老年白血病患者化疗后伴G+球菌感染,临床疗效显著,患者的体温恢复时间、用药时间短,安全性高。

Objective To investigate the clinical efficacy and adverse reactions of linezolid in the treatment of gram-positive coccal infections after chemotherapy in older adult patients with leukemia.Methods Ninety-two older adult patients with leukemia complicated by gram-positive coccal infections,who received treatment in Yiwu Central Hospital from January 2017 to December 2019,were included in this study.They were randomly assigned to receive routine anti-infection treatment(control group,n=46)or linezolid treatment(observation group,n=46).Clinical efficacy,the time required for body temperature restoring to normal,and medication time were compared between the two groups.Results Total response rate was significantly higher in the observation group than in the control group[95.65%(44/46)vs.78.26%(36/46),χ^(2)=6.13,P=0.013].The time required for body temperature restoring to normal and medication time in the observation group were(7.98±1.04)days and(8.58±1.31)days,respectively,which were significantly shorter than those in the control group[(8.85±1.47)days,(9.46±2.52)days,t=3.27,2.10,P=0.001,0.019).The incidence of adverse reactions was significantly lower in the observation group than in the control group[4.35%(2/46)vs.19.57%(9/46),χ^(2)=5.05,P<0.05].Conclusion Linezolid is highly effective on gram-positive coccal infections after chemotherapy in older adult patients with leukemia.Linezolid treatment requires comparatively shorter time required for body temperature restoring to normal and shorter medication time and is safer than routine anti-infection treatment.