POSEIDON标准及其在辅助生殖中的应用

POSEIDON stratification and its application in assisted reproduction

卵巢低反应(poor ovarian response,POR)通常被认为是卵巢储备低下以及卵巢对外源性促性腺激素的反应较差。欧洲人类生殖与胚胎学学会(European Society of Human Reproduction and Embryology,ESHRE)2011年制定的Bologna标准对POR的诊断标准达成了首次共识,但该人群存在异质性,给其治疗带来了很多困难和疑惑。2016年提出的POSEIDON标准,可根据POR人群异质性特征进行分层,精确定义各层人群的临床特征和诊断标准,从而对POR各层人群进行精准治疗,改善其临床治疗结局。本文就最新的POSEIDON标准的提出背景、人群分层特点和对应治疗研究进展做一综述。

Poor ovarian response(POR)is usually defined as low ovarian reserve and poor ovarian response to exogenous gonadotropins.The Bologna criteria proposed by the European Society of Human Reproduction and Embryology(ESHRE)in 2011 reached the initial consensus on the diagnostic criteria for POR,but the heterogeneity of these patients has posed many difficulties and doubts on treatment.The POSEIDON criteria,proposed in 2016,allow for stratification based on the heterogeneous features of POR patients and the accurate definition of clinical characteristics and diagnostic criteria for each stratum,leading to precise treatment and improved clinical outcomes for POR patients.This article reviews the background of the latest POSEIDON criteria,the characteristics of the stratified population and the progress of corresponding treatment studies.