摘要
黏酸属于己糖二酸,可以由果胶的主要成分D-半乳糖醛酸氧化制备。黏酸结构、性质与葡萄糖二酸类似,可应用于重要平台化合物、聚合物、高分子材料的制备。与目前受到广泛关注的葡萄糖二酸合成相比,黏酸合成的研究工作尚处于起步阶段。果胶是一种廉价、丰富的可再生生物质资源,以果胶为原料生物转化制备黏酸具有重要的经济价值和环保意义。文中主要综述了果胶的结构及其水解,微生物代谢D-半乳糖醛酸的生物途径、调控及基于相应途径代谢改造菌株生产黏酸的方法,并展望了黏酸的应用前景,提出了生物法制备黏酸的后续研究方向。
Mucic acid is a hexaric acid that can be biosynthesized by oxidation of D-galacturonic acid,which is the main constituent of pectin.The structure and properties of mucic acid are similar to that of glucaric acid,and can be widely applied in the preparation of important platform compounds,polymers and macromolecular materials.Pectin is a cheap and abundant renewable biomass resource,thus developing a process enabling production of mucic acid from pectin would be of important economic value and environmental significance.This review summarized the structure and hydrolysis of pectin,the catabolism and regulation of D-galacturonic acid in microorganisms,and the strategy for mucic acid production based on engineering of corresponding pathways.The future application of mucic acid are prospected,and future directions for the preparation of mucic acid by biological method are also proposed.
作者
谭黄虹
王静
刘青
郑兆娟
欧阳嘉
TAN Huanghong;WANG Jing;LIU Qing;ZHENG Zhaojuan;OUYANG Jia(College of Chemical Engineering,Nanjing Forestry University,Nanjing 210037,Jiangsu,China)
出处
《生物工程学报》
CAS
CSCD
北大核心
2022年第2期666-677,共12页
Chinese Journal of Biotechnology
基金
国家自然科学基金(22078163)。
