结核病分子生物学检测技术研究进展

Research progress of molecular biology detection technology for tuberculosis

随着医学科学技术的不断发展,特别是精准诊疗时代的来临,分子生物学检测技术在结核病早期诊断辅助方面受到广泛重视和应用。分子生物学检测技术具有准确、高效、高通量等优点,为结核病的诊疗及疫情的防控带来了新曙光。本文中,笔者综合国内外学者研究成果,阐述了基于核酸扩增试验技术、核酸分子杂交技术、基因测序的结核病检测及药物敏感性分析技术和其他新型结核病检测技术的应用现状及其最新研究进展,以期为结核病的辅助诊断提供参考。

With the continuous development of medical science and technology,especially the advent of the era of precise diagnosis and treatment,molecular biology detection technology has been widely valued and applied in the early diagnosis of tuberculosis.Molecular biological detection technology has the advantages of accuracy,high efficiency and high throughput,which brings a new dawn for the diagnosis and treatment of tuberculosis and the prevention and control of the epidemic.Researches at home and abroad were summarized to expound the application status and the latest research progress based on nucleic acid amplification test technology,gene sequencing tuberculosis detection and drug sensitivity analysis technology and other new tuberculosis detection technology,in order to provide reference for the auxiliary diagnosis of tuberculosis.