纳米炭混悬液在甲状腺乳头状癌患者行内镜手术治疗中的应用效果

Application effects of nano-carbon suspension in endoscopic surgery for patients with papillary thyroid carcinoma

目的:观察纳米炭混悬液在甲状腺乳头状癌患者行内镜手术治疗中的应用效果。方法:回顾性分析2020年6月至2021年6月该院收治的120例甲状腺乳头状癌患者的临床资料。根据术中操作分为对照组和观察组各60例。两组均行完全胸乳入路腔镜甲状腺患侧腺叶、峡部切除及患侧中央6组淋巴结清扫术。观察组术中将纳米炭混悬液注射至患侧甲状腺腺体内,对照组无此操作,比较两组中央区淋巴结清扫数目,术前和术后1 d甲状旁腺激素、血钙水平,甲状旁腺误切发生率,以及并发症发生率。结果:观察组清扫中央区淋巴结(6.24±2.02)枚,多于对照组的(3.12±1.03)枚,差异有统计学意义(P<0.05);术后,两组血钙、甲状旁腺激素水平均低于术前,但观察组高于对照组,差异有统计学意义(P<0.05);观察组甲状旁腺误切发生率为0,低于对照组的20.00%,差异有统计学意义(P<0.05);观察组并发症发生率为3.33%,低于对照组的16.67%,差异有统计学意义(P<0.05)。结论:纳米炭混悬液应用在甲状腺乳头状癌患者内镜手术中,可提高淋巴结清扫数目、血钙水平和甲状旁腺激素水平,降低甲状旁腺误切发生率和并发症发生率。

Objective:To observe application effects of nano-carbon suspension in endoscopic surgery for patients with papillary thyroid carcinoma.Methods:The clinical data of 120 patients with papillary thyroid cancer admitted to our hospital from June 2020 to June 2021 were retrospectively analyzed.According to the intraoperative manipulations,they were divided into control group and observation group,60 cases in each group.Both groups underwent total thyroid lobectomy,isthmus resection and dissection of 6 groups of central lymph nodes of the affected side.During the surgery,the observation group was injected with the nano-carbon suspension into the thyroid gland of the affected side,while the control group had no other manipulations.The number of dissected central lymph nodes,the levels of parathyroid hormone and blood calcium before and 1 day after the surgery,the incidence of parathyroid miscut and the incidence of complications were compared between the two groups.Results:There were statistical difference in the number of dissected central lymph nodes between the observation group(6.24±2.02)and the control group(3.12±1.03).After the surgery,the levels of serum calcium and parathyroid hormone in the two groups were lower than those before the surgery;those of the observation group were higher than those of the control group;and the differences were statistically significant(P<0.05).The incidence of parathyroid miscut in the observation group was 0,which was lower than 20.00%in the control group,and the difference was statistically significant(P<0.05).Further,the incidence of complications in the observation group was 3.33%,which was lower than 16.67%in the control group,and the difference was statistically significant(P<0.05).Conclusions:The nano-carbon suspension for the endoscopic surgery of the patients with papillary thyroid cancer can increase the number of lymph nodes dissected,the blood calcium level and parathyroid hormone level,and reduce the incidence of parathyroid miscut and the incidence of complications.