补肾健骨汤联合经皮椎体成形术治疗骨质疏松性胸腰椎压缩骨折患者的效果

Effects of Bushen Jiangu decoction combined with percutaneous vertebroplasty in treatment of osteoporotic thoracolumbar compression fractures

目的:观察补肾健骨汤联合经皮椎体成形术治疗骨质疏松性胸腰椎压缩骨折患者的效果。方法:选取62例骨质疏松性胸腰椎压缩骨折患者为研究对象,按照随机数字表法分为观察组与对照组各31例。对照组行经皮椎体成形术治疗,观察组在对照组治疗基础上联合补肾健骨汤治疗,比较两组疗效、骨钙素(BGP)水平、骨密度、Oswestry功能障碍指数(ODI)、伤椎前缘高度比、伤椎楔变角、后凸Cobb角和并发症发生率。结果:观察组治疗总有效率为87.10%,明显高于对照组的64.52%,差异有统计学意义(P<0.05);术后6周,两组BGP水平和骨密度均高于术前,且观察组明显高于对照组,两组ODI水平均低于术前,且观察组明显低于对照组,差异有统计学意义(P<0.05);术后1、3个月,两组伤椎楔变角和后凸Cobb角均低于术前,且观察组低于对照组,两组伤椎前缘高度比均高于术前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:补肾健骨汤联合经皮椎体成形术治疗骨质疏松性胸腰椎压缩骨折患者可提高治疗总有效率、BGP水平、骨密度和伤椎前缘高度比,以及降低ODI、伤椎楔变角、后凸Cobb角和并发症发生率,效果优于单纯经皮椎体成形术治疗。

Objective:To observe effects of Bushen Jiangu decoction combined with percutaneous vertebroplasty in treatment of osteoporotic thoracolumbar compression fractures.Methods:62 patients with osteoporotic thoracolumbar vertebral compression fractures were selected as the research objects,and were divided into observation group and control group according to the random number table method,31 cases in each.The control group was treated with percutaneous vertebroplasty,while the observation group was treated with Bushen Jiangu decoction on the basis of the treatment in the control group.The curative effects,the osteocalcin(BGP)level,the bone mineral density,the Oswestry disability index(ODI),the height of the anterior edge of the injured vertebra,the wedge angle of the injured vertebra,the kyphotic Cobb angle and the incidence of complications were compared between the two groups.Results:The total effective rate of the observation group was 87.10%,which was significantly higher than the control group of 64.52%,and the difference was statistically significant(P<0.05).6 weeks after the surgery,the BGP levels and the bone mineral densities of the two groups were higher than those before the surgery,and those of the observation group were significantly higher than those of the control group;the ODI levels of the two groups were lower than those before the surgery,and that of the observation group was significantly lower than that of the control group;and the differences were statistically significant Significance(P<0.05).1 and 3 months after the surgery,the wedge angle and the kyphotic Cobb angle of the injured vertebra in both groups were lower than those before the surgery,and those of the observation group was lower than those of the control group;the heights of the anterior edge of the injured vertebra in both groups were higher than those before the surgery,and that of the observation group was higher than that of the control group;and the differences were statistically significant(P<0.05).Further,the incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions:Bushen Jiangu decoction combined with percutaneous vertebroplasty in the treatment of osteoporotic thoracolumbar compression fractures can improve the total effective rate,the BGP level,the bone mineral density and the anterior height of the injured vertebra,and reduce the ODI,the wedge angle of the injured vertebra,the Kyphotic Cobb angle and the complication rate.Moreover,it is superior to simple percutaneous vertebroplasty.