左、右半结肠癌基因表达差异的研究

Study on the Gene Expression Difference Between Left and Right Colorectal Carcinoma

结肠癌是常见的消化道肿瘤之一,左、右半结肠癌在胚胎来源、临床特征、流行病学特征、组织学特征、分子生物学特征以及治疗和预后等方面均存在差异。近年来随着分子生物学的发展,有关左、右半结肠癌相关基因表达的研究越来越多,为结肠癌的发生发展、临床个体化治疗、预后评估提供了新的思路。本文就左、右半结肠癌p53、SMAD4、KRAS、BRAF基因作一综述,以期为左右半结肠癌的临床诊疗提供参考。

Colorectal carcinoma is one of the most common digestive tract tumors.There are differences between left and right colorectal carcinoma in embryological origin,clinical characteristics,epidemiological characteristics,histological characteristics,molecular biological characteristics,treatment and prognosis.In recent years,with the development of molecular biology,more and more studies have been conducted on the expression of genes related to left and right colorectal carcinoma,which provides a new idea for the development,clinical individualized treatment and prognosis evaluation of colorectal carcinoma.This article reviews the p53,SMAD4,KRAS and BRAF genes in left and right colon cancer,in order to provide reference for the clinical diagnosis and treatment of left and right colorectal carcinoma.