丁苯酞对缺血性脑卒中患者神经功能缺损程度影响的临床研究

Clinical Study on the Effect of Butylphthalide on Neurological Deficits in Patients with Ischemic Stroke

目的评价丁苯酞氯化钠注射液治疗缺血性脑卒中的安全性和有效性。方法选取2019年4月-2020年4月在我院诊治的124例缺血性脑卒中患者为研究对象,采用随机数字表法分为试验组和对照组,各62例。两组均给予基础治疗,试验组在此基础上加用丁苯酞氯化钠注射液,对照组在基础治疗上给予等量生理盐水。比较两组神经功能缺损评分(NIHSS)、联合血管事件发生率、日常生活自理能力评分、不良反应发生率及不同随访时间复发率。结果两组NIHSS评分均降低,且试验组低于对照组(P<0.05);试验组联合血管事件发生率为12.90%,与对照组的9.68%比较,差异无统计学意义(P>0.05);两组日常生活自理能力评分高于治疗前,且试验组高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);随访3、6、12个月,试验组总复发率均小于对照组(P<0.05)。结论丁苯酞治疗缺血性脑卒中效果确切,可降低神经功能缺损评分,促进神经功能恢复,提高患者日常生活能力,降低远期复发率,且不增加联合血管事件和不良反应。

Objective To evaluate the safety and efficacy of butylphthalide and sodium chloride injection in the treatment of ischemic stroke.Methods A total of 124 patients with ischemic stroke treated in our hospital from April 2019 to April 2020 were selected and randomly divided into experimental group and control group,with 62 cases in each group.Both groups were given basic treatment,and the experimental group was given butylphthalide sodium chloride injection on the basis of the basic treatment,while the control group was given the same amount of normal saline.The neurological deficit score(NIHSS),incidence of combined vascular events,daily living self-care ability score,incidence of adverse reactions and recurrence rate at different follow-up time were compared between the two groups.Results The NIHSS scores of the two groups decreased,and the experimental group was lower than that in the control group(P <0.05).The incidence of combined vascular events in the experimental group was12.90%,which was not significantly different from 9.68% in the control group(P>0.05).The scores of daily living self-care ability in the two groups were higher than those before treatment,and those in the experimental group were higher than the control group( P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).After 3,6,12 months of follow-up,the total recurrence rate of the experimental group was higher than that of the control group(P<0.05).Conclusion Butylphthalide is effective in the treatment of ischemic stroke,which can reduce the neurological deficit score,promote the recovery of neurological function,improve the daily living ability of patients,reduce the long-term recurrence rate,and do not increase the combined vascular events and adverse reactions.