绝经年龄与女性急性脑梗死患者NIHSS评分的相关性研究

Correlation Between Menopausal Age and NIHSS Score in Female Patients with Acute Cerebral Infarction

目的探讨绝经年龄(MA)与女性急性脑梗死患者NIHSS评分的关系。方法选取2017年6月1日-2020年6月1日云南省中医医院神经内科及老年病区收治的434例绝经后女性急性脑梗死患者的临床资料,根据绝经年龄分为MA<46岁组56例、46≤MA≤52岁组288例和MA>52岁组90例。收集患者一般资料,评估NIHSS评分,分析绝经年龄和NIHSS评分的相关性。结果MA<46岁组及46≤MA≤52岁组大动脉粥样硬化型及小动脉闭塞型患者多于MA>52岁组,MA>52岁组心源性栓塞型、小动脉闭塞型患者多于MA<46岁组及46≤MA≤52岁组,差异有统计学意义(P<0.05);MA<46岁组脑梗死患者NIHSS评分高于46≤MA≤52岁组和MA>52岁组,46≤MA≤52岁组脑梗死患者NIHSS评分高于MA>52岁组,差异有统计学意义(P<0.05);绝经年龄和NIHSS评分呈负相关(r=-0.875,P=0.000)。结论绝经年龄与女性急性脑梗死患者NIHSS评分呈负相关,绝经年龄越早的女性脑梗死患者,神经功能缺损程度越重。

Objective To investigate the relationship between menopausal age(MA)and NIHSS score in female patients with acute cerebral infarction.Methods A total of 434 postmenopausal women with acute cerebral infarction admitted to the Department of Neurology and geriatrics of Yunnan Provincial Hospital of Traditional Chinese Medicine from June 1,2017 to June 1,2020 were selected.According to menopausal age,they were divided into MA<46 years old group(n=56),46 years old group≤MA≤52 years old group(n=288)and MA>52 years old group(n=90).The general data of patients were collected,the NIHSS score was evaluated,and the correlation between menopause age and NIHSS score was analyzed.Results Patients with large artery atherosclerosis and small artery occlusion in MA<46 years old group and 46 years old group≤MA≤52 years old group were more than those in MA>52 years old group,patients with cardiogenic embolism and small artery occlusion in MA>52 years old group were more than those in MA<46 years old group and 46 years old group≤MA≤52 years old group,and the difference was statistically significant(P<0.05).NIHSS score of patients with cerebral infarction in MA<46 years old group was higher than that in 46 years old group≤MA≤52 years old group and MA>52 years old group,and NIHSS score of patients with cerebral infarction in 46 years old group≤MA≤52 years old group was higher than that in MA>52 years old group,and the difference was statistically significant(P<0.05).There was a negative correlation between menopause age and NIHSS score(r=-0.875,P=0.000).Conclusion The menopause age is negatively correlated with the NIHSS score of female patients with acute cerebral infarction.The earlier the age of menopause is,the more severe the neurological deficit is.