磷酸肌酸钠与果糖二磷酸钠治疗小儿心肌炎的疗效比较

Comparison of the efficacy of creatine phosphate sodium and fructose diphosphate sodium in children with myocarditis

目的探讨磷酸肌酸钠在小儿心肌炎中的应用价值。方法 100例小儿心肌炎患儿,根据随机数字表法分为研究组和对照组,每组50例。研究组患儿给予磷酸肌酸钠治疗,对照组患儿给予果糖二磷酸钠治疗。对比两组患儿治疗前后心肌酶谱(肌钙蛋白I、肌酸激酶、乳酸脱氢酶及肌酸激酶同工酶)、左心室射血分数和二尖瓣口舒张早期血流速度与舒张晚期血流速度比值(E/A)。结果治疗后,两组患儿肌钙蛋白I、肌酸激酶、乳酸脱氢酶及肌酸激酶同工酶水平均较本组治疗前降低,且研究组患儿肌钙蛋白I(0.12±0.02)μg/L、肌酸激酶(215.01±67.85)U/L、乳酸脱氢酶(256.63±88.94)U/L、肌酸激酶同工酶(26.12±2.12)U/L低于对照组的(0.71±0.13)μg/L、(544.56±144.73)U/L、(479.12±111.01)U/L、(52.13±14.81)U/L,差异具有统计学意义(P<0.05)。治疗后,两组患儿左心室射血分数、E/A均较本组治疗前提高,且研究组患儿左心室射血分数(63.27±7.55)%、E/A(1.56±0.35)高于对照组的(55.21±8.14)%、(1.07±0.17),差异具有统计学意义(P<0.05)。结论磷酸肌酸钠在小儿心肌炎治疗中的应用价值高,能改善心功能指标,减少心肌损害,值得推广使用。

Objective To discuss the application value of creatine phosphate sodium in children with myocarditis.Methods A total of 100 children with myocarditis were divided into research group and control group according to the random numerical table,with 50 cases in each group.Children in the research group were treated with creatine phosphate sodium,and children in the control group were treated with fructose diphosphate sodium.Both groups were compared in terms of myocardial enzymogram(troponin I,creatine kinase,lactate dehydrogenase and creatine kinase isoenzyme),left ventricular ejection fraction and early diastolic peak flow velocity of mitral valve/late diastolic peak flow velocity of mitral valve(E/A) before and after treatment.Results After treatment,the troponin I,creatine kinase,lactate dehydrogenase and creatine kinase isoenzymes of the two groups were lower than those of this group before treatment;the troponin I(0.12±0.02) μg/L,creatine kinase(215.01±67.85) U/L,lactate dehydrogenase(256.63±88.94) U/L,creatine kinase isoenzyme(26.12±2.12) U/L of the research group were lower than(0.71±0.13) μg/L,(544.56±144.73) U/L,(479.12±111.01) U/L,(52.13±14.81) U/L of the control group;all the differences were statistically significant(P<0.05).After treatment,the left ventricular ejection fraction and E/A of the two groups were higher than those of this group before treatment;the left ventricular ejection fraction(63.27±7.55)% and E/A(1.56±0.35) of the research group were higher than(55.21±8.14)% and(1.07±0.17) of the control group;all the differences were statistically significant(P<0.05).Conclusion Creatine phosphate sodium has a high application value in children with myocarditis,and it can improve myocardial function indexes and reduce myocardial damage.It is worthy of popularization and application.