摘要
P2X3受体属于嘌呤能受体P2X受体家族中的一员,主要表达于初级感觉神经元中。ATP作为P2X3受体的天然配体,在病理状态如神经损伤、心肌缺血时释放显著增加。与ATP结合后,P2X3受体将外周信号传入神经中枢,进一步引起病理生理变化。研究证实P2X3受体与各种病理性疼痛,尤其是炎症性疼痛有关。近年来发现P2X3受体在高血压、缺血性心肌损害、心肌梗死、糖尿病心脏自主神经损害等心血管系统疾病中也发挥重要作用。现就P2X3受体的分子结构、分布、功能特性及其在心血管疾病中的研究进展进行综述。
P2 X3 receptor, a member of the purinergic receptor P2 X receptor family, is mainly expressed in primary sensory neurons.ATP,as the natural ligand of P2 X3 receptor, is significantly increased in pathological conditions such as nerve injury and myocardial ischemia.After binding with ATP,P2 X3 receptor transmits peripheral signals to the nerve center, further causing pathophysiological changes.P2 X3 receptor has been confirmed in various pathologic pain, especially inflammatory pain.In recent years, studies have also found that P2 X3 receptor plays an important role in cardiovascular diseases such as hypertension, myocardial ischemic injury, myocardial infarction and diabetic heart autonomic nerve injury.This paper summarizes the molecular structure, distribution, functional characteristics of P2 X3 receptor and its research progress in cardiovascular diseases.
作者
杨双
唐艳红
YANG Shuang;TANG Yanhong(Department of Cardiology,Renmin Hospital of Wuhan University,Cardiovascular Research Institute of Wuhan University,Hubei Key Laboratory of Cardiology,Wuhan 430060,Hubei,China)
出处
《心血管病学进展》
CAS
2022年第2期117-119,136,共4页
Advances in Cardiovascular Diseases
基金
国家自然科学基金(U1504802)。
关键词
P2X3受体
高血压
糖尿病心脏自主神经病变
心肌缺血
心血管疾病
P2X3 receptor
Hypertension
Diabetic heart autonomic nerve injury
Myocardial infarction
Cardiovascular diseases
