大动脉炎加速冠状动脉粥样硬化机制的研究进展

Mechanism of Accelerated Atherosclerosis in Takayasu Arteritis

大动脉炎是一种慢性、非特异性、肉芽肿性血管炎,先前研究认为其参与冠状动脉狭窄的主要机制是主动脉炎症扩展至冠状动脉,导致内膜增生及中外膜纤维化挛缩。近年来,大量研究发现大动脉炎患者的冠状动脉粥样硬化程度及心血管疾病发生率明显升高,且传统的心血管危险因素(高脂血症、高血压、糖尿病、吸烟和衰老等)并不能完全解释心血管疾病风险增加的原因。现对大动脉炎加速冠状动脉粥样硬化进展的发病机制进行概述。

Takayasu arteritis(TA) is a chronic, nonspecific, granulomatous vasculitis that has previously been implicated in coronary artery stenosis mainly through aortic inflammation extending into the coronary artery, resulting in intimal hyperplasia and fibrous contracture of the medial membrane.In recent years, a large number of studies have found that the degree of coronary atherosclerosis and the morbidity of cardiovascular disease are significantly increased in patients with TA,but the traditional cardiovascular risk factors(hyperlipidemia, hypertension, diabetes, smoking, aging, etc.) cannot fully explain the increased risk of cardiovascular disease.In this article, we summarize the pathogenesis of TA accelerating the progression of coronary atherosclerosis.