2型糖尿病合并糖尿病性周围神经病理性疼痛的危险因素

Risk Factors of Type 2 Diabetes Mellitus with Diabetic Peripheral Neuropathic Pain

目的探讨2型糖尿病(T2DM)合并糖尿病性周围神经病理性疼痛(DPNP)的危险因素,为其防控提供依据。方法选取2020年1月至2021年2月河南省荣军医院收治的178例T2DM住院患者为研究对象,按是否合并周围神经病理性疼痛分为疼痛组(62例)和非疼痛组(116例)。收集患者临床资料并进行危险因素分析。结果T2DM发生DPNP的发病率为34.83%;单因素分析结果显示,疼痛组和非疼痛组白蛋白、糖尿病病程、糖化血红蛋白、空腹血糖以及糖尿病视网膜病变、糖尿病合并外周动脉疾病比较,差异有统计学意义(P<0.05);多因素分析结果显示白蛋白低、糖尿病病程长、糖化血红蛋白高、糖尿病视网膜病变是T2DM发生DPNP的独立危险因素(P<0.05)。结论T2DM发生DPNP的独立危险因素有白蛋白低、糖尿病病程长、糖化血红蛋白高、糖尿病视网膜病变,临床应早期识别以上危险因素,对其进行有效干预,以期减少此类疾病的发生。

Objective To investigate the risk factors of type 2 diabetes mellitus(T2DM)combined with diabetic peripheral neuropathic pain(DPNP),and to provide evidence for its prevention and control.Methods A total of 178 inpatients with T2DM admitted to Henan Rongjun Hospital from January 2020 to February 2021 were selected as the research objects.According to whether they had peripheral neuropathic pain,they were divided into pain group(62 cases)and non-pain group(116 cases).The clinical data were collected for risk factor analysis.Results The incidence of DPNP in T2DM was 34.83%.The univariate analysis showed that there were statistical significant differences in albumin,diabetes course,glycosylated hemoglobin,fasting blood glucose,diabetic retinopathy and diabetes with peripheral arterial disease between the pain group and the non-pain group(P<0.05).The results of multivariate analysis showed that low albumin,long course of diabetes,high glycosylated hemoglobin and diabetic retinopathy were independent risk factors for DPNP in T2DM(P<0.05).Conclusion The independent risk factors for DPNP in T2DM include low albumin,long course of diabetes,high glycosylated hemoglobin and diabetic retinopathy.The above risk factors should be identified early in the clinic and effective interventions should be carried out to reduce the occurrence of such diseases.