中医药网络药理学:《指南》引领下的新时代发展

Traditional Chinese medicine network pharmacology:development in new era under guidance of network pharmacology evaluation method guidance

中医药凭借整体观和两千多年来临床使用天然药物的实践经验,在疾病的预防和治疗中有独特优势。中医药诊疗思想和丰富临床经验中的"整体"特色孕育了以"网络"和"系统"为特色的新一代研究模式。该模式在生物医学大数据和人工智能时代得到了快速发展,其中有代表性的研究领域——"网络药理学"为人工智能与中西医学交叉研究、分析海量生物医学数据、建立从数据到知识的转换提供了新的思路和方法。中医药领域在提出"网络靶标"核心理论、促进网络药理学起源和发展过程中起着关键作用,并且率先制订了第一个网络药理学国际标准《网络药理学评价方法指南》。在理论上,网络靶标能够机制性关联药物与疾病,并定量表示药物整体调节作用机制;在方法上,网络药理学朝向计算、实验和临床相结合的研究模式发展。该文介绍了中医药网络药理学近期在预测药物靶点、理解药物和疾病的生物学基础、寻找病证标志物等方面取得的重要进展。随着《网络药理学评价方法指南》的提出,网络药理学的发展有望越来越规范、健康,基于网络靶标的中医药研发模式将产生更多高质量研究成果,有力促进中医药现代化和国际化。

Traditional Chinese medicine(TCM)has unique advantages in the prevention and treatment of diseases owing to its holistic view and more than 2000 years of experience in the clinical use of natural medicine.The"holistic"characteristic of TCM gives birth to a new generation of research paradigm featuring"network"and"system",which has been developing rapidly in the era of biomedical big data and artificial intelligence.Network pharmacology,a representative research field,provides new ideas and methods for the research of the interdiscipline of artificial intelligence and medicine,the analysis of massive biomedical data,and the transformation from data to knowledge.TCM plays an important role in proposing the core theory of"network target"and promoting the establishment and development of network pharmacology,and has taken the lead in formulating the first international standard of network pharmacology--Network Pharmacology Evaluation Method Guidance.In terms of theory,network target can systematically link drugs and diseases and quantitatively interpret the overall regulatory mechanism of drugs.In the aspect of method,network pharmacology is developing towards a research model that combines computational,experimental,and clinical approaches.This review introduces the resent important progress of TCM network pharmacology in predicting drug targets,understanding the biological basis of drugs and diseases,and searching for disease and syndrome biomarkers.Under the guidance of Network Pharmacology Evaluation Method Guidance,the development of network pharmacology is expected to become more and more standardized and healthy.Network target will help produce more high-quality research outcomes in TCM and effectively boost the modernization and internationalization of TCM.