精子形态对年轻女性新鲜单囊胚移植助孕结局的影响

Effect of sperm morphology on the pregnant outcomes of fresh single blastocyst transfer in young women

目的探讨精子形态对年轻(≤35岁)女性行新鲜单囊胚移植助孕结局的影响。方法回顾性分析2019年1至12月在温州医科大学附属第二医院生殖医学中心行新鲜单囊胚移植的年轻女性患者690例,根据男方精子形态正常率分为正常组157例、精子轻中度畸形组256例、精子重度畸形组277例,比较3组患者实验室结局、妊娠结局和新生儿结局。结果3组患者进行体外受精胚胎移植助孕后优质囊胚形成率、囊胚冷冻数等实验室结局和临床妊娠率、活产率、流产率、婴儿出生体重、新生儿性别等妊娠结局及新生儿结局比较差异均无统计学意义(均P>0.05)。多因素logistic回归分析显示精子形态异常不是影响活产结局的因素(P>0.05)。结论年轻女性行新鲜单囊胚移植时,精子形态异常既不影响体外受精实验室结局,也不影响妊娠结局及新生儿结局,为精子形态异常患者选择新鲜单囊胚移植助孕的安全性提供一定的参考价值。

Objective To investigate the impact of sperm morphology on pregnancy outcome of fresh single blastocyst transfer in young women.Methods The clinical data of 690 women aged≤35 years,who underwent fresh single blastocyst transfer cycle for in vitro fertilization and embryo transfer(IVF-ET)in the Reproductive Medicine Center of the Second Affiliated Hospital of Wenzhou Medical University from January 2019 to December 2019,were analyzed retrospectively.According to the normal rate of male sperm morphology,the patients were divided into three groups:157 cases in normal sperm morphology group,256 cases in mild to moderate teratozoospermia group and 277 cases in severe teratozoospermia group.The laboratory outcomes,pregnancy outcomes and neonatal outcomes of the three groups were compared.Results There was no significant difference in the general information of the three groups before IVF-ET(P>0.05).There were significant differences in high-quality blastocyst formation rate,blastocyst freezing number,clinical pregnancy rate,live birth rate,abortion rate,infant birth weight and neonatal sex composition ratio after IVF-ET among three groups(all P>0.05).Multivariate logistic regression analysis showed that sperm morphology was not a significant factor for the outcome of live births(P>0.05).Conclusion Abnormal sperm morphology does not affect the lab outcomes,pregnancy outcomes or neonatal outcomes during fresh single blastocyst transfer cycle of IVF-ET,which provides a reference for individuals with abnormal sperm morphology to choose fresh single blastocyst transfer in IVF-ET.